acetoacetate

1. (S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate

Catalysed by ADHFE1

1. transport of 2-hydroxybutyrate and acetoacetate (cytosol to extracellular)

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A1extracellular space, cytosolOne of 2 routes

1. Acetoacetate:CoA ligase (AMP-forming)

Catalysed by AACScytosolOne of 3 routes

1. Acetoacetate carboxy-lyase (acetone-forming)

No catalyst recordedmitochondrial matrix

1. transport of acetoacetate and pyruvate (cytosol to mitochondria)

No catalyst recordedmitochondrial matrix, cytosolOne of 4 routes

1. transport of acetoacetate and retinoate (cytosol to extracellular)

Catalysed by SLC16A4, SLC16A5extracellular space, cytosolOne of 2 routes

1. (R)-3-Hydroxybutanoate:NAD+ oxidoreductase

Catalysed by BDH1, BDH2mitochondrial matrixOne of 4 routes

1. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

Catalysed by FAH

1. transport of acetate and acetoacetate (cytosol to extracellular)

Catalysed by SLC16A4, SLC16A5, SLC16A6, SLC16A7 and 1 moreextracellular space, cytosolOne of 2 routes

1. transport of acetoacetate and formate (cytosol to extracellular)

Catalysed by SLC16A4, SLC16A5extracellular space, cytosolOne of 2 routes

1. transport of acetoacetate and propanoate (cytosol to extracellular)

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 1 moreextracellular space, cytosolOne of 2 routes

1. transport of acetoacetate and butyrate (cytosol to extracellular)

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 1 moreextracellular space, cytosolOne of 2 routes

1. transport of acetoacetate and L-lactate (cytosol to extracellular)

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 1 moreextracellular space, cytosolOne of 2 routes

1. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA

Catalysed by HMGCL, HMGCLL1

1. acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate

Catalysed by AACSOne of 2 routes

1. Acetoacetate:CoA ligase (AMP-forming)
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)

Catalysed by AACS, HMGCS1cytosolOne of 3 routes

1. transport of acetoacetate and L-lactate (cytosol to extracellular)
2. Transport of Prostaglandin E3, Lactate Antiport

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 1 moreextracellular space, cytosolOne of 2 routes