ferricytochrome c

Three steps

• L-leucineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and leucine (cytosol to extracellular)

  Catalysed by LDHD, AGXT2, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 14 routes

• 10-formyltetrahydrofolic acidReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A7 and 3 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• CHEBI:15699Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and homoserine (cytosol to extracellular)

  Catalysed by LDHD, AGXT2, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 6 routes

• formateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)
  3. oxalate(in) + formate(out) = oxalate(out) + formate(in)

  Catalysed by SUOX, SLC25A14, SLC26A2, SLC25A30 and 2 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• nicotinic acid D-ribonucleotideReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. Transport of Quinolinic Acid
  3. Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating)

  Catalysed by SUOX, SLC22A6, QPRTmitochondrial matrix, cytosol, extracellular space

• N-carbamoyl-L-aspartic acidReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by SUOX, SLC25A14, SLC25A30, CADmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• CHEBI:15971Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and histidine (cytosol to extracellular)

  Catalysed by LDHD, AGXT2, SLC7A6mitochondrial matrix, cytosol, extracellular spaceOne of 5 routes

• androsteroneReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. steroid sulfatase (androsterone sulfate)
  3. steroid sulfatase (androsterone sulfate)

  Catalysed by SUOX, STSmitochondrial matrix, cytosolOne of 3 routes

• CHEBI:16174Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. pyruvate kinase (dTDP)
  3. nucleoside-diphosphate kinase (dADP)

  Catalysed by LDHD, PKM, PKLR, NME4 and 5 moremitochondrial matrix, cytosolOne of 3 routes

• L-cystineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by LDHD, AGXT2, SLC7A9, SLC3A1mitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• CHEBI:16284Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. pyruvate kinase (dTDP)
  3. deoxythymidylate kinase (dADP)

  Catalysed by LDHD, PKM, PKLR, DTYMKmitochondrial matrix, cytosolOne of 3 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (S)-3-amino-2-methylpropionate transaminase (2-methyl-3-oxopropanoate)

  Catalysed by LDHD, AGXT2, ABATmitochondrial matrix, cytosolOne of 3 routes

• 17beta-hydroxy-5alpha-androstan-3-oneReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. steroid sulfatase (5-alpha-dihydrotestosterone)
  3. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by SUOX, STSmitochondrial matrix, cytosolOne of 3 routes

• L-citrullineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and citrulline (cytosol to extracellular)

  Catalysed by LDHD, AGXT2, SLC7A6mitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• iodideReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by SUOX, SLC26A6, SLC26A4mitochondrial matrix, cytosol, extracellular space

• L-valineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and valine (cytosol to extracellular)

  Catalysed by LDHD, AGXT2, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 13 routes

• L-arginineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and arginine (cytosol to extracellular)

  Catalysed by LDHD, AGXT2, SLC7A6mitochondrial matrix, cytosol, extracellular spaceOne of 10 routes

• CHEBI:16497Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. pyruvate kinase (dTDP)
  3. dGTP:pyruvate 2-O-phosphotransferase

  Catalysed by LDHD, PKM, PKLRmitochondrial matrix, cytosol

• protein polypeptide chainReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. PROTEIN_BS

  Catalysed by LDHD, AGXT2mitochondrial matrix, cytosolOne of 3 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, cytosol, extracellular space

• pregnenoloneReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. Steryl-Sulfatase
  3. Pregnenolone-sulfate sulfohydrolase

  Catalysed by SUOX, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 4 routes

• CHEBI:16633Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by LDHD, AGXT2, SCLYmitochondrial matrix, cytosol

• Met-tRNA(Met)Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by LDHD, TYW1B, TYW1, MARS1mitochondrial matrix, cytosol

• (R)-glycerateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. L-Serine:pyruvate aminotransferase
  3. D-glycerate:NADP+ 2-oxidoreductase

  Catalysed by LDHD, AGXT, GRHPRmitochondrial matrix, cytosolOne of 4 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by LDHD, TYW1B, TYW1, AADATmitochondrial matrix, cytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by LDHD, LDHA, LDHB, LDHC and 3 moremitochondrial matrix, cytosol

• CHEBI:16857Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and threonine (cytosol to extracellular)

  Catalysed by LDHD, AGXT2, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 8 routes

• N-acetyl-L-aspartateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by SUOX, SLC25A14, SLC25A30, NAT8Lmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• glycolaldehydeReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. L-Serine:pyruvate aminotransferase
  3. hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)

  Catalysed by LDHD, AGXTmitochondrial matrix, cytosolOne of 2 routes

• aldehydo-N-acetyl-D-mannosamineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by LDHD, NPLmitochondrial matrix, cytosolOne of 2 routes

• L-isoleucineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and isoleucine (cytosol to extracellular)

  Catalysed by LDHD, AGXT2, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 8 routes

• CHEBI:17203Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and proline (cytosol to extracellular)

  Catalysed by LDHD, AGXT2, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 9 routes

• 17alpha-hydroxyprogesteroneReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, cytosol, extracellular space, endoplasmic reticulum

• estroneReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. estrone 3-sulfate + H2O = estrone + sulfate + H(+)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by SUOX, STSmitochondrial matrix, cytosolOne of 3 routes

• propanoateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by SUOX, STS, SLC22A9mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• enol-oxaloacetateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by LDHD, ME2, SDHB, SDHAmitochondrial matrix, cytosol

• AH2Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by LDHD, AGXT2, MOCOSmitochondrial matrix, cytosolOne of 7 routes

• L-cysteineReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and cysteine (cytosol to extracellular)

  Catalysed by LDHD, AGXT2, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 23 routes

• 3,3'-diiodo-L-thyronineReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. Steryl-Sulfatase
  3. Steryl-Sulfatase

  Catalysed by SUOX, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 3 routes

• Ala-tRNA(Ala)Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by LDHD, AGXT2, AARS1mitochondrial matrix, cytosol

• glycine betaineReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SUOX, SLC26A6, SLC6A12mitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• 4-methylumbelliferyl acetateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 5 moremitochondrial matrix, cytosol, extracellular space

• urateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (S)-Lactate:NAD+ oxidoreductase
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by LDHD, LDHB, LDHAL6B, SLC22A12mitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• CHEBI:17895Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and tyrosine (cytosol to extracellular)

  Catalysed by LDHD, AGXT2, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 10 routes

• all-trans-retinalReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, cytosol, extracellular space

• butanoateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)

  Catalysed by SUOX, STS, SLC22A9mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• 3-phenylpyruvateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. L-Glutamine:pyruvate aminotransferase
  3. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine

  Catalysed by LDHD, KYAT1mitochondrial matrix, cytosol

• CHEBI:18019Reach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and lysine (cytosol to extracellular)

  Catalysed by LDHD, AGXT2, SLC7A6mitochondrial matrix, cytosol, extracellular spaceOne of 5 routes

• thiocyanateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)

  Catalysed by LDHD, MPST, TSTmitochondrial matrix, cytosolOne of 3 routes

• 4-fumarylacetoacetateReach from here →
  1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by LDHD, FAHmitochondrial matrix, cytosolOne of 2 routes