a quinone

Three steps

• (S,S)-tartrateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by SDHB, SLC25A10, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by SDHB, SLC25A10, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by SDHB, SLC25A10, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by SQOR, ETHE1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• cis-aconitic acidReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SDHB, FH, SLC25A1cytosol, mitochondrial matrixOne of 3 routes

• N-carbamoyl-L-aspartateReach from here →
  1. a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)
  2. (S)-dihydroorotate + a quinone = orotate + a quinol
  3. (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H(+)

  Catalysed by CYC1, UQCRFS1, DHODH, CADouter side of the membrane

• a carboxylic esterReach from here →
  1. (S)-dihydroorotate + a quinone = orotate + a quinol
  2. orotate(out) + a carboxylate(in) = orotate(in) + a carboxylate(out)
  3. a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)

  Catalysed by DHODH, SLC22A13, CES2, CES1 and 3 moreinner side of the membrane, outer side of the membrane

• serotoninReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and serotonin (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• an acylcholineReach from here →
  1. (S)-dihydroorotate + a quinone = orotate + a quinol
  2. orotate(out) + a carboxylate(in) = orotate(in) + a carboxylate(out)
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by DHODH, SLC22A13, BCHEinner side of the membrane, outer side of the membrane

• glycochenodeoxycholateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by SQOR, ETHE1, ABCC4inner side of the membrane, outer side of the membrane

• taurocholateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. solute carrier organic anion transporter (GSH)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 3 routes

• glyoxylateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by SDHB, FH, CLYBLcytosol

• D-fructoseReach from here →
  1. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  2. beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate
  3. beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate

  Catalysed by GPD2, ALDOB, IMPA1, DCPH1

• glycolithocholic acidReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of glycolithocholate and GSH (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• phosphoenolpyruvic acidReach from here →
  1. (R)-malate + a quinone = enol-oxaloacetate + a quinol
  2. oxaloacetate = enol-oxaloacetate
  3. GTP:oxaloacetate carboxy-lyase (adding GTP

  Catalysed by SDHB, SDHA, FAHD2B, FAHD1 and 2 morecytosolOne of 2 routes

• tert-butanolReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by SQOR, ETHE1, CLIC2, GPX1 and 3 more

• L-ornithineReach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. aldehyde dehydrogenase (1-pyrroline-5-carboxylate)
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by PRODH, PRODH2, ALDH4A1, OATcytosol, mitochondrial matrixOne of 3 routes

• gamma-Glu-AlaReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SQOR, ETHE1, GGT1, GGT5 and 4 moremitochondrial matrix, extracellular space, cytosol

• a thioesterReach from here →
  1. (S)-dihydroorotate + a quinone = orotate + a quinol
  2. orotate(out) + a carboxylate(in) = orotate(in) + a carboxylate(out)
  3. a thioester + H2O = a thiol + a carboxylate + H(+)

  Catalysed by DHODH, SLC22A13, PNKDinner side of the membrane, outer side of the membrane

• 3,3',5-triiodo-L-thyronineReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and triiodothyronine (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• a 3-acylpyruvateReach from here →
  1. (S)-dihydroorotate + a quinone = orotate + a quinol
  2. orotate(out) + a carboxylate(in) = orotate(in) + a carboxylate(out)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by DHODH, SLC22A13, FAHD1inner side of the membrane, outer side of the membrane

• glycineReach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. transport of glycine and proline (cytosol to extracellular)

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2 and 2 morecytosol, extracellular spaceOne of 2 routes

• (S)-malyl-CoAReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

  Catalysed by SDHB, FH, SUCLG1, SUCLA2cytosol

• prostaglandin E1Reach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and prostaglandin E1 (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• prostaglandin I2Reach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and prostaglandin I2 (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• prostaglandin H2Reach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and prostaglandin H2 (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• prostaglandin D2Reach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by SQOR, ETHE1, GPX5, GPX1 and 7 moremitochondrial matrix, cytosolOne of 2 routes

• leukotriene A4Reach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and leukotriene A4 (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• (R)-S-lactoylglutathioneReach from here →
  1. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  2. dihydroxyacetone phosphate = methylglyoxal + phosphate
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by GPD2, TPI1, GLO1, GLOD4cytosolOne of 5 routes

• nicotinate beta-D-ribonucleotideReach from here →
  1. (S)-dihydroorotate + a quinone = orotate + a quinol
  2. orotate(out) + nicotinate(in) = orotate(in) + nicotinate(out)
  3. 5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate

  Catalysed by DHODH, SLC22A12, NAPRTinner side of the membrane, outer side of the membrane

• 1-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  2. dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)

  Catalysed by GPD2, GNPAT, DHRS7B

• a long-chain fatty acidReach from here →
  1. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  2. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA
  3. a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)

  Catalysed by GPD2, GNPAT, AGPS

• (2R)-3-phospho-glyceroyl phosphateReach from here →
  1. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  2. D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
  3. D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)

  Catalysed by GPD2, TPI1, GAPDHS, GAPDH

• beta-D-fructose 6-phosphateReach from here →
  1. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  2. beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
  3. beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate

  Catalysed by GPD2, ALDOA, ALDOB, ALDOC and 2 moreOne of 4 routes

• S-formylglutathioneReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by SQOR, ETHE1, ADH1C, ADH1A and 4 moremitochondrial matrix, cytosolOne of 2 routes

• L-methionineReach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. transport of methionine and proline (cytosol to extracellular)

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2 and 1 morecytosol, extracellular spaceOne of 3 routes

• N-sulfo-D-glucosamineReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SDHB, SLC25A10, SGSHmitochondrial matrix, cytosol

• dehydroepiandrosterone 3-sulfateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)

  Catalysed by SDHB, SLC25A10, STSmitochondrial matrix, cytosol

• L-tryptophanReach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. transport of proline and tryptophan (cytosol to extracellular)

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2 and 2 morecytosol, extracellular spaceOne of 4 routes

• L-threonineReach from here →
  1. a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)
  2. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
  3. trans-4-hydroxy-L-proline(out) + L-threonine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-threonine(out) + Na(+)(in)

  Catalysed by CYC1, UQCRFS1, PRODH2, SLC1A4outer side of the membrane, inner side of the membraneOne of 2 routes

• L-alanineReach from here →
  1. a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)
  2. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by CYC1, UQCRFS1, PRODH, PRODH2 and 1 moreouter side of the membrane, inner side of the membraneOne of 7 routes

• leukotriene C4Reach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. leukotriene C4 synthase (GSH)

  Catalysed by SQOR, ETHE1, LTC4Smitochondrial matrix, cytosolOne of 5 routes

• L-asparagineReach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. transport of asparagine and proline (cytosol to extracellular)

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2 and 1 morecytosol, extracellular spaceOne of 4 routes

• IMPReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  3. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)

  Catalysed by SDHB, ADSL, TNRC6B, ADSS2 and 1 morecytosol

• L-phenylalanineReach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. transport of phenylalanine and proline (cytosol to extracellular)

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2 and 1 morecytosol, extracellular spaceOne of 3 routes

• adenosine 5'-phosphosulfateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. ATP:sulfate adenylyltransferase

  Catalysed by SDHB, SLC25A10, PAPSS1, PAPSS2mitochondrial matrix, cytosolOne of 4 routes

• glutathione disulfideReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and thiosulfate (cytosol to mitochondria)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SDHB, SLC25A10, TSTD1mitochondrial matrix, cytosolOne of 36 routes

• taurolithocholate 3-sulfateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes