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Proteins/UNIPROT:Q9H993
Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response..
Function from UniProtKB (Q9H993), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
21 statements
21 statements · 3 reference databases · Subject: DCPH1 · Sources: Hetionet, Rhea, UniProt
3 reactions
L-glutamyl-[protein]+S-adenosyl-L-methionine[protein]-L-glutamate 5-O-methyl ester+S-adenosyl-L-homocysteine
Catalysed by DCPH1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:24452CC BY 4.0Reference data
beta-D-fructose 6-phosphatedihydroxyacetone+D-glyceraldehyde 3-phosphate
Catalysed by DCPH1
Reaction pageDirection not assertedBalanced
Rhea RHEA:28002CC BY 4.0Reference data
8 names
Resolves to: DCPH1
Reaction pageLeft to rightBalanced
Rhea RHEA:35603CC BY 4.0Reference data