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Proteins/UNIPROT:P29218
Phosphatase involved in the dephosphorylation of myo-inositol monophosphates to generate myo-inositol. Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate. Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP. Responsible for the provision of inositol required for synthesis of phosphatidylinositols and polyphosphoinositides, and involved in maintaining normal brain function. Has been implicated as the pharmacological target for lithium (Li(+)) action in brain, which is used to treat bipolar affective disorder. Is equally active with 1D-myo-inositol 1-phosphate, 1D-myo-inositol 3-phosphate and D-galactose 1-phosphate..
Function from UniProtKB (P29218), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
151 statements
151 statements · 7 reference databases · Subject: IMPA1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
17 reactions
water+1D-myo-inositol 1-phosphatemyo-inositol+phosphate(3-)
Reaction pageLeft to rightBalancedEC 3.1.3.25cytosol
Human-GEM MAR06540CC BY 4.0Reference data
MAM00530c+watermyo-inositol+phosphate(3-)
6 names
Resolves to: IMPA1
Human-GEM MAR06562CC BY 4.0Reference data
1D-myo-inositol 3-phosphate+watermyo-inositol+phosphate(3-)
Reaction pageLeft to rightBalancedEC 3.1.3.25cytosol
Human-GEM MAR06571CC BY 4.0Reference data
glycerol 2-phosphate+waterglycerol+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:13105CC BY 4.0Reference data
D-glucose 6-phosphate+waterD-glucose+hydrogenphosphate
Catalysed by IMPA1 or G6PC1 or G6PC3 or G6PC2
Reaction pageLeft to rightBalanced
Rhea RHEA:16689CC BY 4.0Reference data
alpha-D-glucose 1-phosphate+waterD-glucose+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:19933CC BY 4.0Reference data
CHEBI:84139+watermyo-inositol+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:24056CC BY 4.0Reference data
1D-myo-inositol 1-phosphate+watermyo-inositol+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:27670CC BY 4.0Reference data
alpha-D-galactose 1-phosphate+waterD-galactose+hydrogenphosphate
Catalysed by IMPA1
Reaction pageLeft to rightBalanced
Rhea RHEA:29315CC BY 4.0Reference data
CHEBI:58469+watermyo-inositol+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:30735CC BY 4.0Reference data
1D-myo-inositol 3-phosphate+watermyo-inositol+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:30739CC BY 4.0Reference data
beta-D-fructose 1-phosphate+waterD-fructose+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:35603CC BY 4.0Reference data