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Proteins/UNIPROT:P05062
Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde. Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check..
Function from UniProtKB (P05062), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
64 statements
64 statements · 8 reference databases · Subject: ALDOB · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
8 reactions
MAM03960cCHEBI:16108+MAM01981c
Catalysed by ALDOB
Reaction pageReversibleBalancedEC 4.1.2.13cytosol
Human-GEM MAR01038CC BY 4.0Reference data
CHEBI:16108+D-erythrose 4-phosphateMAM02883c
Reaction pageLeft to rightBalancedEC 4.1.2.13cytosol
Human-GEM MAR04355CC BY 4.0Reference data
2 names
Resolves to: ALDOB
Reaction pageReversibleBalancedEC 4.1.2.13cytosol
Human-GEM MAR04356CC BY 4.0Reference data
CHEBI:16108+CHEBI:29052MAM01841c
Catalysed by ALDOC or ALDOB or ALDOA
Reaction pageReversibleBalancedEC 4.1.2.13cytosol
Human-GEM MAR04375CC BY 4.0Reference data
MAM01746cCHEBI:16108+MAM01981c
Catalysed by ALDOC or ALDOB or ALDOA
Reaction pageReversibleBalancedEC 4.1.2.13cytosol
Human-GEM MAR08762CC BY 4.0Reference data
D-ribulose 1-phosphateCHEBI:16108+glycolaldehyde
Catalysed by ALDOC or ALDOB or ALDOA
Reaction pageReversibleBalancedEC 4.1.2.13cytosol
Human-GEM MAR08773CC BY 4.0Reference data
beta-D-fructose 1,6-bisphosphateD-glyceraldehyde 3-phosphate+dihydroxyacetone phosphate
Catalysed by ALDOA or ALDOB or ALDOC
Reaction pageReversibleBalanced
Rhea RHEA:14729CC BY 4.0Reference data
beta-D-fructose 1-phosphateD-glyceraldehyde+dihydroxyacetone phosphate
Catalysed by ALDOB
Reaction pageReversibleBalanced
Rhea RHEA:30851CC BY 4.0Reference data