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Proteins/UNIPROT:P60174
Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis..
It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids..
Function from UniProtKB (P60174), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
916 statements
916 statements · 6 reference databases · Subject: TPI1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
3 reactions
Catalysed by TPI1
Reaction pageReversibleBalancedEC 5.3.1.1cytosol
Human-GEM MAR04391CC BY 4.0Reference data
dihydroxyacetone phosphatemethylglyoxal+hydrogenphosphate
Catalysed by TPI1
Reaction pageDirection not assertedBalanced
Rhea RHEA:17937CC BY 4.0Reference data
4 names
Resolves to: TPI1
Catalysed by TPI1
Reaction pageReversibleBalanced
Rhea RHEA:18585CC BY 4.0Reference data