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Proteins/UNIPROT:P04075
Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis. In addition, also functions as a scaffolding protein (By similarity). In response to glucose deprivation, FBP dissociates from aldolase and acts as an adapter that promotes AMP-activated protein kinase (AMPK) activity: mechanistically, associates with transient receptor potential channels TrpV (TRPV1-TRPV4), promoting inhibition of the V-ATPase complex on lysosomes and AMPK activation via the AXIN1-STK11/LKB1 axis (By similarity)..
Function from UniProtKB (P04075), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
454 statements
454 statements · 8 reference databases · Subject: ALDOA · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
5 reactions
CHEBI:16108+MAM01981cketo-D-fructose 1-phosphate
Catalysed by ALDOC or ALDOB or ALDOA
Reaction pageReversibleBalancedEC 4.1.2.13cytosol
Human-GEM MAR04356CC BY 4.0Reference data
CHEBI:16108+CHEBI:29052MAM01841c
Catalysed by ALDOC or ALDOB or ALDOA
Reaction pageReversibleBalancedEC 4.1.2.13cytosol
3 names
Resolves to: ALDOA
Human-GEM MAR04375CC BY 4.0Reference data
MAM01746cCHEBI:16108+MAM01981c
Catalysed by ALDOC or ALDOB or ALDOA
Reaction pageReversibleBalancedEC 4.1.2.13cytosol
Human-GEM MAR08762CC BY 4.0Reference data
D-ribulose 1-phosphateCHEBI:16108+glycolaldehyde
Catalysed by ALDOC or ALDOB or ALDOA
Reaction pageReversibleBalancedEC 4.1.2.13cytosol
Human-GEM MAR08773CC BY 4.0Reference data
beta-D-fructose 1,6-bisphosphateD-glyceraldehyde 3-phosphate+dihydroxyacetone phosphate
Catalysed by ALDOA or ALDOB or ALDOC
Reaction pageReversibleBalanced
Rhea RHEA:14729CC BY 4.0Reference data