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Proteins/UNIPROT:Q6IAN0
Reductase required for adipogenesis and activation of PPARG nuclear receptor. Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively, synthesizing ether-linked phospholipids that act as agonists for PPARG. Also regulates adipogenesis by preventing adipocyte browning: following import into the nucleus, interacts with PRDM16, inhibiting the interaction between PRDM16 and PPARG and preventing differentiation of brown adipocytes..
Function from UniProtKB (Q6IAN0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
27 statements
27 statements · 4 reference databases · Subject: DHRS7B · Sources: Hetionet, Reactome, Rhea, WikiPathways
2 reactions
1-hexadecanoyl-sn-glycero-3-phosphate+NADP(3-)1-hexadecanoylglycerone 3-phosphate+NADPH(4-)+hydron
Catalysed by DHRS7B
Reaction pageDirection not assertedBalanced
Rhea RHEA:17341CC BY 4.0Reference data
a 1-O-alkylglycerone 3-phosphate+NADPH(4-)+hydrona 1-O-alkyl-sn-glycero-3-phosphate+NADP(3-)
Catalysed by DHRS7B
5 names
Resolves to: DHRS7B
Rhea RHEA:36175CC BY 4.0Reference data