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Reference

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Reach

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D-fructose

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

7 compounds within 3 steps: 1 in 1, 2 in 2, 4 in 3

Does it reach a compound?

One step

D-fructose 6-phosphateReach from here →
1. D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)
Catalysed by HK1, GCK, HK2, HK3

Two steps

D-glucosamine 6-phosphateReach from here →
1. D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)
2. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate
Catalysed by HK1, GCK, HK2, HK3 and 2 more
D-mannose 6-phosphateReach from here →
1. D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)
2. D-mannose 6-phosphate = D-fructose 6-phosphate
Catalysed by HK1, GCK, HK2, HK3 and 1 more

Three steps

2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactoneReach from here →
Catalysed by HK1, GCK, HK2, HK3 and 3 more
N-acetyl-D-glucosamine 6-phosphateReach from here →

Catalysed by HK1, GCK, HK2, HK3 and 3 moreOne of 2 routes

alpha-D-mannose 1-phosphateReach from here →

D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)
D-mannose 6-phosphate = D-fructose 6-phosphate
alpha-D-mannose 1-phosphate = D-mannose 6-phosphate

Catalysed by HK1, GCK, HK2, HK3 and 3 more

D-glucose 6-phosphateReach from here →

D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)
D-mannose 6-phosphate = D-fructose 6-phosphate
D-glucose 6-phosphate = D-mannose 6-phosphate

Catalysed by HK1, GCK, HK2, HK3 and 2 more