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Proteins/UNIPROT:O14556
Catalyzes the conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate in glycolysis and the reverse reaction in gluconeogenesis (By similarity). May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity)..
Function from UniProtKB (O14556), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
21 statements
21 statements · 7 reference databases · Subject: GAPDHS · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea
2 reactions
(2R)-3-phospho-glyceroyl phosphate+proton+NADH(2-)CHEBI:29052+NAD(+)+phosphate(3-)
Reaction pageReversibleBalancedEC 1.2.1.12cytosol
Human-GEM MAR04373CC BY 4.0Reference data
D-glyceraldehyde 3-phosphate+hydrogenphosphate+NAD(1-)(2R)-3-phospho-glyceroyl phosphate
6 names
Resolves to: GAPDHS
Reaction pageReversibleBalanced
Rhea RHEA:10300CC BY 4.0Reference data