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Proteins/UNIPROT:Q53H96
Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate (P5C) to L-proline using NAD(P)H. Proline is synthesized from either glutamate or ornithine; both are converted to P5C, and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCR3 is exclusively linked to the biosynthesis of proline from ornithine..
Function from UniProtKB (Q53H96), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
66 statements
66 statements · 5 reference databases · Subject: PYCR3 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
8 reactions
(S)-1-pyrroline-5-carboxylate+2proton+NADPH(4-)NADP(3-)+CHEBI:17203
Reaction pageLeft to rightBalancedEC 1.5.1.2cytosol
Human-GEM MAR03833CC BY 4.0Reference data
(S)-1-pyrroline-5-carboxylate+2proton+NADH(2-)NAD(+)+CHEBI:17203
4 names
Resolves to: PYCR3
Reaction pageLeft to rightBalancedEC 1.5.1.2cytosol
Human-GEM MAR03835CC BY 4.0Reference data
NAD(+)+CHEBI:180952proton+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+NADH(2-)
Catalysed by PYCR3 or PYCR2 or PYCR1
Reaction pageLeft to rightBalancedEC 1.5.1.2cytosol
Human-GEM MAR04778CC BY 4.0Reference data
NAD(+)+CHEBI:180952proton+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+NADH(2-)
Catalysed by PYCR3 or PYCR2 or PYCR1
Reaction pageLeft to rightBalancedEC 1.5.1.2mitochondrial matrix
Human-GEM MAR04779CC BY 4.0Reference data
NADP(3-)+CHEBI:180952proton+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+NADPH(4-)
Catalysed by PYCR3 or PYCR2 or PYCR1
Reaction pageLeft to rightBalancedEC 1.5.1.2cytosol
Human-GEM MAR04780CC BY 4.0Reference data
NADP(3-)+CHEBI:180952proton+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+NADPH(4-)
Catalysed by PYCR3 or PYCR2 or PYCR1
Reaction pageLeft to rightBalancedEC 1.5.1.2mitochondrial matrix
Human-GEM MAR04781CC BY 4.0Reference data
L-proline+NAD(1-)(S)-1-pyrroline-5-carboxylate+NADH(2-)+2hydron
Catalysed by PYCR1 or PYCR3 or PYCR2
Reaction pageRight to leftBalanced
Rhea RHEA:14105CC BY 4.0Reference data
L-proline+NADP(3-)(S)-1-pyrroline-5-carboxylate+NADPH(4-)+2hydron
Catalysed by PYCR1 or PYCR3 or PYCR2
Reaction pageRight to leftBalanced
Rhea RHEA:14109CC BY 4.0Reference data