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Proteins/UNIPROT:Q96C36
Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H. At physiologic concentrations, has higher specific activity in the presence of NADH. Involved in cellular response to oxidative stress. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+)..
Function from UniProtKB (Q96C36), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
45 statements
45 statements · 6 reference databases · Subject: PYCR2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
10 reactions
(S)-1-pyrroline-5-carboxylate+2proton+NADPH(4-)NADP(3-)+CHEBI:17203
Reaction pageLeft to rightBalancedEC 1.5.1.2cytosol
Human-GEM MAR03833CC BY 4.0Reference data
(S)-1-pyrroline-5-carboxylate+2proton+NADH(2-)NAD(+)+CHEBI:17203
2 names
Resolves to: PYCR2
Reaction pageLeft to rightBalancedEC 1.5.1.2cytosol
Human-GEM MAR03835CC BY 4.0Reference data
(S)-1-pyrroline-5-carboxylate+2proton+NADH(2-)NAD(+)+CHEBI:17203
Reaction pageLeft to rightBalancedEC 1.5.1.2mitochondrial matrix
Human-GEM MAR03837CC BY 4.0Reference data
NAD(+)+CHEBI:180952proton+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+NADH(2-)
Catalysed by PYCR3 or PYCR2 or PYCR1
Reaction pageLeft to rightBalancedEC 1.5.1.2cytosol
Human-GEM MAR04778CC BY 4.0Reference data
NAD(+)+CHEBI:180952proton+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+NADH(2-)
Catalysed by PYCR3 or PYCR2 or PYCR1
Reaction pageLeft to rightBalancedEC 1.5.1.2mitochondrial matrix
Human-GEM MAR04779CC BY 4.0Reference data
NADP(3-)+CHEBI:180952proton+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+NADPH(4-)
Catalysed by PYCR3 or PYCR2 or PYCR1
Reaction pageLeft to rightBalancedEC 1.5.1.2cytosol
Human-GEM MAR04780CC BY 4.0Reference data
NADP(3-)+CHEBI:180952proton+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+NADPH(4-)
Catalysed by PYCR3 or PYCR2 or PYCR1
Reaction pageLeft to rightBalancedEC 1.5.1.2mitochondrial matrix
Human-GEM MAR04781CC BY 4.0Reference data
(S)-1-pyrroline-5-carboxylate+2proton+NADPH(4-)NADP(3-)+CHEBI:17203
Reaction pageLeft to rightBalancedEC 1.5.1.2mitochondrial matrix
Human-GEM MAR08609CC BY 4.0Reference data
L-proline+NAD(1-)(S)-1-pyrroline-5-carboxylate+NADH(2-)+2hydron
Catalysed by PYCR1 or PYCR3 or PYCR2
Reaction pageRight to leftBalanced
Rhea RHEA:14105CC BY 4.0Reference data
L-proline+NADP(3-)(S)-1-pyrroline-5-carboxylate+NADPH(4-)+2hydron
Catalysed by PYCR1 or PYCR3 or PYCR2
Reaction pageRight to leftBalanced
Rhea RHEA:14109CC BY 4.0Reference data