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Proteins/UNIPROT:O00116

AGPS

Protein·UNIPROT:O00116Alkyldihydroxyacetonephosphate synthase, peroxisomal

Open in the graph

Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis..

Function from UniProtKB (O00116), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

alkylglycerone-phosphate synthase deficiency has a germline basis in AGPSDiseaseGenCC HGNC:327|MONDO:0100274Inferred only
rhizomelic chondrodysplasia punctata type 3 has a germline basis in AGPSDiseaseGenCC HGNC:327|MONDO:0010823Inferred only

Statements

46 statements

46 statements · 7 reference databases · Subject: AGPS · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Search this listOrder

AGPS covaries with ADOProteinHetionet hetionet:covaries:84890-8540Inferred only
COPS6 covaries with AGPSProteinHetionet hetionet:covaries:10980-8540Inferred only
NUDT10 covaries with AGPSProteinHetionet hetionet:covaries:170685-8540Inferred only
AGPS is expressed in bronchusAnatomyHuman Protein Atlas ENSG00000018510Inferred only
AGPS is expressed in cerebellumAnatomyHuman Protein Atlas ENSG00000018510Inferred only
AGPS is expressed in colonAnatomyHuman Protein Atlas ENSG00000018510Inferred only
AGPS is expressed in duodenumAnatomyHuman Protein Atlas ENSG00000018510Inferred only
AGPS is expressed in endometriumAnatomyHuman Protein Atlas ENSG00000018510Inferred only
AGPS is expressed in epididymisAnatomyHuman Protein Atlas ENSG00000018510Inferred only
AGPS is expressed in fallopian tubeAnatomyHuman Protein Atlas ENSG00000018510Inferred only
AGPS is expressed in gallbladderAnatomyHuman Protein Atlas ENSG00000018510Inferred only
AGPS is expressed in mouth mucosaAnatomyHuman Protein Atlas ENSG00000018510Inferred only

Show the remaining 34

AGPS is expressed in placentaAnatomyHuman Protein Atlas ENSG00000018510Inferred only
AGPS is expressed in rectumAnatomyHuman Protein Atlas ENSG00000018510Inferred only
AGPS is expressed in seminal vesicleAnatomyHuman Protein Atlas ENSG00000018510Inferred only
AGPS is expressed in Small intestineAnatomyHuman Protein Atlas ENSG00000018510Inferred only
AGPS is expressed in testisAnatomyHuman Protein Atlas ENSG00000018510Inferred only
AGPS is expressed in thyroid glandAnatomyHuman Protein Atlas ENSG00000018510Inferred only
AGPS is expressed in vermiform appendixAnatomyHuman Protein Atlas ENSG00000018510Inferred only
AGPS is expressed in zone of skinAnatomyHuman Protein Atlas ENSG00000018510Inferred only
GNPAT interacts with AGPSProteinHetionet hetionet:interacts:8443-8540Inferred only
UBC interacts with AGPSProteinHetionet hetionet:interacts:7316-8540Inferred only
AGPS participates in Ether lipid biosynthesisPathwayWikiPathways WP5275Inferred only
AGPS participates in Glycerophospholipid biosynthetic pathwayPathwayWikiPathways WP2533Inferred only
AGPS participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
AGPS participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
AGPS participates in Peroxisomal protein importPathwayReactome R-HSA-9033241Inferred only
AGPS participates in Plasmalogen biosynthesisPathwayReactome R-HSA-75896Inferred only
AGPS participates in Protein localizationPathwayReactome R-HSA-9609507Inferred only
AGPS participates in Triacylglyceride synthesisPathwayWikiPathways WP325Inferred only
AGPS participates in TYSND1 cleaves peroxisomal proteinsPathwayReactome R-HSA-9033500Inferred only
AGPS participates in Wax and plasmalogen biosynthesisPathwayReactome R-HSA-8848584Inferred only
DIABLO increases the expression of AGPSProteinHetionet hetionet:regulates:56616-8540Inferred only
DMTF1 increases the expression of AGPSProteinHetionet hetionet:regulates:9988-8540Inferred only
HOXB13 decreases the expression of AGPSProteinHetionet hetionet:regulates:10481-8540Inferred only
NFE2L2 increases the expression of AGPSProteinHetionet hetionet:regulates:4780-8540Inferred only
NXF1 increases the expression of AGPSProteinHetionet hetionet:regulates:10482-8540Inferred only
ZNF768 increases the expression of AGPSProteinHetionet hetionet:regulates:79724-8540Inferred only
AGPS requires the cofactor FAD(3-)CompoundUniProt O00116Inferred only
1-acylglycerone 3-phosphate is a substrate of AGPSCompoundHuman-GEM MAR07594Inferred only
1-hexadecanoylglycerone 3-phosphate is a substrate of AGPSCompoundRhea RHEA:40659Inferred only
1-hexadecanoylglycerone 3-phosphate is a substrate of AGPSCompoundRhea RHEA:40727Inferred only
a 1-acylglycerone 3-phosphate is a substrate of AGPSCompoundRhea RHEA:36171Inferred only
a long chain fatty alcohol is a substrate of AGPSCompoundRhea RHEA:36171Inferred only
a long-chain fatty acid is a substrate of AGPSCompoundRhea RHEA:40727Inferred only
hexadecan-1-ol is a substrate of AGPSCompoundRhea RHEA:40659Inferred only

Reactions

4 reactions

1-acylglycerone 3-phosphate+MAM03417xa 1-O-alkylglycerone 3-phosphate+proton+fatty acid
Catalysed by AGPS
Reaction pageLeft to rightBalance undeterminableEC 2.5.1.26peroxisome
Human-GEM MAR07594CC BY 4.0Reference data
a long chain fatty alcohol+a 1-acylglycerone 3-phosphatea 1-O-alkylglycerone 3-phosphate+a long-chain fatty acid+hydron
Catalysed by

Other names

3 names

Resolves to: AGPS

Also called: Aging-associated gene 5 proteinAlkyl-DHAP synthaseAlkylglycerone-phosphate synthase

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Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:36171CC BY 4.0Reference data

1-hexadecanoylglycerone 3-phosphate+hexadecan-1-ol1-O-hexadecylglycerone 3-phosphate+hexadecanoate+hydron

Catalysed by AGPS

Reaction pageLeft to rightBalanced

Rhea RHEA:40659CC BY 4.0Reference data

1-hexadecanoylglycerone 3-phosphate+a long-chain fatty acida 1-acylglycerone 3-phosphate+hexadecanoate

Catalysed by AGPS

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:40727CC BY 4.0Reference data