3-(4-hydroxyphenyl)pyruvate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

214 compounds within 3 steps: 5 in 1, 34 in 2, 175 in 3

Three steps

N-carbamoyl-L-aspartateReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)
Catalysed by TAT, SLC7A13, CADinner side of the membrane, outer side of the membrane
3-oxopropanoateReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. glyoxylate + L-alanine = glycine + pyruvate
3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
Catalysed by AADAT, AGXT, AGXT2
thiosulfateReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
3. transport of malate and thiosulfate (cytosol to mitochondria)
Catalysed by AADAT, CLYBL, SLC25A10mitochondrial matrix, cytosolOne of 2 routes
dodecanamideReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate
3. N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate
Catalysed by AADAT, PAM
2-oxohexanoateReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
3. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate
Catalysed by AADAT, AGXT2
D-serineReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. glyoxylate + L-alanine = glycine + pyruvate
3. D-serine = pyruvate + NH4(+)
Catalysed by AADAT, AGXT, AGXT2, SRR
L-alpha-aminobutyric acidReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
3. glutamic-pyruvic transaminase ((S)-2-aminobutanoate)
Catalysed by AADAT, AGXT2, GPTcytosol
5-aminolevulinateReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA
Catalysed by TAT, AADAT, ALAS1, ALAS2
glycochenodeoxycholateReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)
Catalysed by TAT, AADAT, BAAT
glycochenodeoxycholic acidReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
3. bile acid-CoA: amino acid N-acyltransferase
Catalysed by TAT, AADAT, BAATperoxisomeOne of 3 routes
3-hydroxyisovaleric acidReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine
3. 4-methyl-2-oxopentanoate decarboxylation
Catalysed by AADAT, ALOX12B, ALOXE3cytosol
glycolithocholic acidReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
3. bile acid-CoA:amino acid N-acyltransferase (glycine)
Catalysed by TAT, AADAT, BAATcytosolOne of 2 routes
decanamideReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate
3. N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate
Catalysed by AADAT, PAM
L-2-amino-3-oxobutanoic acidReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
3. Acetyl-CoA:glycine C-acetyltransferase
Catalysed by TAT, AADAT, GCATmitochondrial matrix
(R)-lactic acidReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. glyoxylate + L-alanine = glycine + pyruvate
3. (R)-Lactate:NAD+ oxidoreductase
Catalysed by AADAT, AGXT, AGXT2, LDHDcytosol
(S)-lactic acidReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. glyoxylate + L-alanine = glycine + pyruvate
3. (S)-Lactate:NAD+ oxidoreductase
Catalysed by AADAT, AGXT, AGXT2, LDHB and 1 moremitochondrial matrixOne of 5 routes
(6R)-L-erythro-6,7-dihydrobiopterinReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
3. (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O
Catalysed by TAT, TH, PCBD1, PCBD2One of 2 routes
2-iminopropanoateReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. glyoxylate + L-alanine = glycine + pyruvate
3. 2-iminopropanoate + H2O = pyruvate + NH4(+)
Catalysed by AADAT, AGXT, AGXT2, RIDA
phosphoenolpyruvic acidReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. glyoxylate + L-alanine = glycine + pyruvate
3. pyruvate kinase (dTDP)
Catalysed by AADAT, AGXT, AGXT2, PKM and 1 morecytosol
N-acetyl-beta-neuraminic acidReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. glyoxylate + L-alanine = glycine + pyruvate
3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Catalysed by AADAT, AGXT, AGXT2, NPLcytosol
L-ornithineReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
3. transport of ornithine and phenylalanine (cytosol to extracellular)
Catalysed by TAT, PAH, SLC7A6extracellular space, cytosolOne of 9 routes
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-oneReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine
3. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)
Catalysed by AADAT, ADI1
S(8)-aminomethyldihydrolipoamideReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)
Catalysed by TAT, AADAT, GLDC, GCSHmitochondrial matrix
a 3-acylpyruvateReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. glyoxylate + L-alanine = glycine + pyruvate
3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)
Catalysed by AADAT, AGXT, AGXT2, FAHD1
(S)-malyl-CoAReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
Catalysed by AADAT, CLYBL, SUCLG1, SUCLA2
propanoyl-CoAReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
Catalysed by AADAT, CLYBL
sarcosineReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
Catalysed by TAT, AADAT, PIPOXOne of 2 routes
(6S)-5,6,7,8-tetrahydrofolateReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
Catalysed by TAT, AADAT, SHMT1, SHMT2
2-(N(omega)-L-arginino)succinateReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
3. L-Citrulline:L-aspartate ligase (AMP-forming)
Catalysed by TAT, SLC7A13, ASS1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes
N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
3. IMP:L-aspartate ligase (GDP-forming)
Catalysed by TAT, SLC7A13, ADSS2, ADSS1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes
L-histidineReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
3. L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)
Catalysed by TAT, PAH, SLC7A8inner side of the membrane, outer side of the membraneOne of 2 routes
an N-acylglycineReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)
Catalysed by TAT, AADAT, GLYATL3, GLYAT and 1 more
2-oxo-3-sulfanylpropanoateReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. glyoxylate + L-alanine = glycine + pyruvate
3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
Catalysed by AADAT, AGXT, AGXT2, MPST
2-methyl-3-oxopropanoateReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. glyoxylate + L-alanine = glycine + pyruvate
3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
Catalysed by AADAT, AGXT, AGXT2
guanidinoacetateReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
3. L-Arginine:glycine amidinotransferase
Catalysed by TAT, AADAT, GATMcytosolOne of 2 routes
L-methionineReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
3. transport of methionine and phenylalanine (cytosol to extracellular)
Catalysed by TAT, PAH, SLC7A5extracellular space, cytosolOne of 16 routes
L-tryptophanReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
Catalysed by TAT, TH, TPH1, TPH2One of 16 routes
glutathioneReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
Catalysed by TAT, AADAT, GSS
L-threonineReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
3. L-threonine = 2-oxobutanoate + NH4(+)
Catalysed by AADAT, AGXT2, SDS, SDSL
L-kynurenineReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
3. Transport of L-Kynurenine
Catalysed by TAT, PAH, SLC7A8extracellular space, cytosolOne of 2 routes
beta-alanineReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
3. L-aspartate 1-carboxy-lyase (beta-alanine-forming)
Catalysed by TAT, SLC7A13, GAD2inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes
L-alanineReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
3. transport of alanine and phenylalanine (cytosol to extracellular)
Catalysed by TAT, PAH, SLC7A5extracellular space, cytosolOne of 31 routes
leukotriene C4Reach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
3. leukotriene C4 hydrolysis
Catalysed by TAT, AADATcytosol
L-asparagineReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
3. transport of asparagine and phenylalanine (cytosol to extracellular)
Catalysed by TAT, PAH, SLC7A5extracellular space, cytosolOne of 9 routes
N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)
Catalysed by TAT, SLC7A13, AGAinner side of the membrane, outer side of the membrane
N(omega),N(omega)-dimethyl-L-arginineReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
Catalysed by TAT, AADAT, AGXT2One of 8 routes
(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
3. 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)
Catalysed by TAT, SLC7A13, PAICSinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes
(3S)-citramalyl-CoAReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. glyoxylate + L-alanine = glycine + pyruvate
3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA
Catalysed by AADAT, AGXT, AGXT2, CLYBL
L-2-aminoadipateReach from here →
1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
Catalysed by AADAT
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
Catalysed by TAT, AADAT, GLYATL2One of 2 routes