Proteins/UNIPROT:O75342

ALOX12B

ProteinUNIPROT:O75342Arachidonate 12-lipoxygenase, 12R-type1 compound

Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins..

Function from UniProtKB (O75342), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · substrate of

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

all-cis-docosa-4,7,10,13,16,19-hexaenoic acidCompoundCHEBI:28125Inferred only8 paths8 endpoints

What the reference databases state

GenCC submitters' classifications

4 rows

autosomal recessive congenital ichthyosis 2 has a germline basis in ALOX12BDiseaseGenCC HGNC:430|MONDO:0009439Inferred only
congenital non-bullous ichthyosiform erythroderma has a germline basis in ALOX12BDiseaseGenCC HGNC:430|MONDO:0019306Inferred only
lamellar ichthyosis has a germline basis in ALOX12BDiseaseGenCC HGNC:430|MONDO:0017778Inferred only
self-healing collodion baby has a germline basis in ALOX12BDiseaseGenCC HGNC:430|MONDO:0017267Inferred only

Statements

23 statements

23 statements · 9 reference databases · Subject: ALOX12B · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Order

ALOX12B is expressed in skin of legAnatomyBgee ENSG00000179477Inferred only
ALOX12B is expressed in zone of skinAnatomyHuman Protein Atlas ENSG00000179477Inferred only
ALOX12B interacts with KRT5ProteinHetionet hetionet:interacts:242-3852Inferred only
ALOX12B interacts with LMNAProteinHetionet hetionet:interacts:242-4000Inferred only
ALOX12B participates in Arachidonate metabolismPathwayReactome R-HSA-2142753Inferred only
ALOX12B participates in Fatty acid metabolismPathwayReactome R-HSA-8978868Inferred only
ALOX12B participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
ALOX12B participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
ALOX12B participates in Octadecanoid formation from linoleic acidPathwayWikiPathways WP5324Inferred only
ALOX12B participates in Synthesis of 12-eicosatetraenoic acid derivativesPathwayReactome R-HSA-2142712Inferred only
ALOX12B regulates positive regulation of gene expressionBiological processgene ontology O75342|GO:0010628Inferred only
ALOX12B regulates positive regulation of MAPK cascadeBiological processgene ontology O75342|GO:0043410Inferred only

Show the remaining 11

ALOX12B regulates positive regulation of mucus secretionBiological processgene ontology O75342|GO:0070257Inferred only
ALOX12B requires the cofactor iron cationCompoundUniProt O75342Inferred only
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate is a substrate of ALOX12BCompoundRhea RHEA:41344Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is a substrate of ALOX12BCompoundHuman-GEM MAR08545Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is a substrate of ALOX12BCompoundRhea RHEA:41336Inferred only
(8Z,11Z,14Z)-eicosatrienoate is a substrate of ALOX12BCompoundRhea RHEA:43468Inferred only
1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate is a substrate of ALOX12BCompoundRhea RHEA:43480Inferred only
1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate is a substrate of ALOX12BCompoundRhea RHEA:61868Inferred only
1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate is a substrate of ALOX12BCompoundRhea RHEA:41311Inferred only
4-methyl-2-oxopentanoate is a substrate of ALOX12BCompoundHuman-GEM MAR06924Inferred only
all-cis-docosa-4,7,10,13,16,19-hexaenoic acid is a substrate of ALOX12BCompoundRhea RHEA:43472Inferred only

Reactions

18 reactions

4-methyl-2-oxopentanoate+dioxygen3-hydroxyisovaleric acid+carbon dioxide
Catalysed by ALOXE3 or ALOX12B
Reaction pageLeft to rightBalancedEC 1.13.11.-cytosol
Human-GEM MAR06924CC BY 4.0Reference data
(5Z,8Z,11Z,14Z)-eicosatetraenoate+dioxygenMAM00306c
Catalysed by ALOX12B
Reaction pageLeft to rightBalancedEC 1.13.11.-cytosol
Human-GEM MAR08545

Other names

3 names

Resolves to: ALOX12B

Also called: 12R-lipoxygenase12R-LOXEpidermis-type lipoxygenase 12

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CC BY 4.0

Reference data

CHEBI:134621+dioxygenCHEBI:134624

Catalysed by ALOX12B

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:40495CC BY 4.0Reference data

CHEBI:77888+dioxygenCHEBI:77889

Catalysed by ALOX12B

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:41239CC BY 4.0Reference data

1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate+dioxygenCHEBI:78034

Catalysed by ALOX12B

Reaction pageLeft to rightBalanced

Rhea RHEA:41311CC BY 4.0Reference data

(5Z,8Z,11Z,14Z)-eicosatetraenoate+dioxygen(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

Catalysed by ALOX12B

Reaction pageLeft to rightBalanced

Rhea RHEA:41336CC BY 4.0Reference data

CHEBI:32391+dioxygenCHEBI:78070

Catalysed by ALOX12B

Reaction pageLeft to rightBalanced

Rhea RHEA:41340CC BY 4.0Reference data

(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate+dioxygen(5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate

Catalysed by ALOX12B

Reaction pageLeft to rightBalanced

Rhea RHEA:41344CC BY 4.0Reference data

CHEBI:69080+dioxygenCHEBI:78040

Catalysed by ALOX12B

Reaction pageLeft to rightBalanced

Rhea RHEA:41756CC BY 4.0Reference data

(8Z,11Z,14Z)-eicosatrienoate+dioxygenCHEBI:83334

Catalysed by ALOX12B

Reaction pageLeft to rightBalanced

Rhea RHEA:43468CC BY 4.0Reference data

all-cis-docosa-4,7,10,13,16,19-hexaenoic acid+dioxygen14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate

Catalysed by ALOX12B

Reaction pageLeft to rightBalanced

Rhea RHEA:43472CC BY 4.0Reference data

CHEBI:32391+dioxygenCHEBI:83342

Catalysed by ALOX12B

Reaction pageLeft to rightBalanced

Rhea RHEA:43476CC BY 4.0Reference data

Show the remaining 6