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Proteins/UNIPROT:P24298

GPT

Protein·UNIPROT:P24298Alanine aminotransferase 1

Open in the graph

Pyridoxal enzyme tha catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. By mediating the conversion of these four major intermediate metabolites, plays an important role in gluconeogenesis and amino acid metabolism..

Function from UniProtKB (P24298), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

45 statements

45 statements · 8 reference databases · Subject: GPT · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

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GPT covaries with ACOT4ProteinHetionet hetionet:covaries:122970-2875Inferred only
GPT covaries with MYL10ProteinHetionet hetionet:covaries:2875-93408Inferred only
GPT is expressed in adrenal glandAnatomyHuman Protein Atlas ENSG00000167701Inferred only
GPT is expressed in apex of heartAnatomyBgee ENSG00000167701Inferred only
GPT is expressed in bronchusAnatomyHuman Protein Atlas ENSG00000167701Inferred only
GPT is expressed in colonAnatomyHuman Protein Atlas ENSG00000167701Inferred only
GPT is expressed in duodenumAnatomyHuman Protein Atlas ENSG00000167701Inferred only
GPT is expressed in endometriumAnatomyHuman Protein Atlas ENSG00000167701Inferred only
GPT is expressed in gallbladderAnatomyHuman Protein Atlas ENSG00000167701Inferred only
GPT is expressed in liverAnatomyHuman Protein Atlas ENSG00000167701Inferred only
GPT is expressed in mucosa of transverse colonAnatomyBgee ENSG00000167701Inferred only
GPT is expressed in nasopharynxAnatomyHuman Protein Atlas ENSG00000167701Inferred only

Show the remaining 33

GPT is expressed in ovaryAnatomyHuman Protein Atlas ENSG00000167701Inferred only
GPT is expressed in placentaAnatomyHuman Protein Atlas ENSG00000167701Inferred only
GPT is expressed in rectumAnatomyHuman Protein Atlas ENSG00000167701Inferred only
GPT is expressed in right lobe of liverAnatomyBgee ENSG00000167701Inferred only
GPT is expressed in Small intestineAnatomyHuman Protein Atlas ENSG00000167701Inferred only
GPT is expressed in stomachAnatomyHuman Protein Atlas ENSG00000167701Inferred only
GPT is expressed in testisAnatomyHuman Protein Atlas ENSG00000167701Inferred only
GPT is expressed in urinary bladderAnatomyHuman Protein Atlas ENSG00000167701Inferred only
GPT is expressed in uterine cervixAnatomyHuman Protein Atlas ENSG00000167701Inferred only
GPT is expressed in vermiform appendixAnatomyHuman Protein Atlas ENSG00000167701Inferred only
GPT is expressed in zone of skinAnatomyHuman Protein Atlas ENSG00000167701Inferred only
CAPN1 interacts with GPTProteinHetionet hetionet:interacts:2875-823Inferred only
GPT interacts with CDC7ProteinHetionet hetionet:interacts:2875-8317Inferred only
GPT participates in Aerobic glycolysis augmentedPathwayWikiPathways WP4628Inferred only
GPT participates in Aerobic respiration and respiratory electron transportPathwayReactome R-HSA-1428517Inferred only
GPT participates in Alanine and aspartate metabolismPathwayWikiPathways WP106Inferred only
GPT participates in Alanine metabolismPathwayReactome R-HSA-8964540Inferred only
GPT participates in Biomarkers for urea cycle disordersPathwayWikiPathways WP4583Inferred only
GPT participates in Cori cyclePathwayWikiPathways WP1946Inferred only
GPT participates in Krebs cycle disordersPathwayWikiPathways WP4236Inferred only
GPT participates in Metabolic epileptic disordersPathwayWikiPathways WP5355Inferred only
GPT participates in Metabolic reprogramming in pancreatic cancerPathwayWikiPathways WP5220Inferred only
GPT participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
GPT participates in Metabolism of amino acids and derivativesPathwayReactome R-HSA-71291Inferred only
GPT participates in Pyruvate metabolismPathwayReactome R-HSA-70268Inferred only
GPT participates in Urea cycle and associated pathwaysPathwayWikiPathways WP4595Inferred only
GPT requires the cofactor pyridoxal 5'-phosphateCompoundUniProt P24298Inferred only
2-oxobutanoate is a substrate of GPTCompoundHuman-GEM MAR06970Inferred only
L-alanine is a substrate of GPTCompoundHuman-GEM MAR03899Inferred only
L-alanine is a substrate of GPTCompoundRhea RHEA:19453Inferred only
L-alpha-aminobutyric acid is a substrate of GPTCompoundHuman-GEM MAR06970Inferred only
pyruvate is a substrate of GPTCompoundRhea RHEA:19453Inferred only
pyruvate is a substrate of GPTCompoundHuman-GEM MAR03899Inferred only

Reactions

4 reactions

2-oxoglutarate(2-)+L-alanineL-glutamate(1-)+pyruvate
Catalysed by GPT
Reaction pageReversibleBalancedEC 2.6.1.2cytosol
Human-GEM MAR03899CC BY 4.0Reference data
L-alpha-aminobutyric acid+2-oxoglutarate(2-)2-oxobutanoate+L-glutamate(1-)
Catalysed by GPT
Reaction pageReversibleBalancedEC 2.6.1.2cytosol

Other names

8 names

Resolves to: GPT

Also called: AAT1ALT1Glutamate pyruvate transaminaseGlutamate pyruvate transaminase 1Glutamic--alanine transaminase 1Glutamic--pyruvic transaminase 1GPT-1GPT1

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Human-GEM MAR06970

CC BY 4.0

Reference data

MAM00830c+2-oxoglutarate(2-)L-glutamate(1-)+MAM04073c

Catalysed by GPT2 or GPT

Reaction pageReversibleBalancedEC 2.6.1.2cytosol

Human-GEM MAR11467CC BY 4.0Reference data

L-alanine+2-oxoglutarate(2-)pyruvate+L-glutamate(1-)

Catalysed by GPT or GPT2

Reaction pageDirection not assertedBalanced

Rhea RHEA:19453CC BY 4.0Reference data