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Proteins/UNIPROT:P22234
Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway..
Function from UniProtKB (P22234), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
111 statements
111 statements · 6 reference databases · Subject: PAICS · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid+protonMAM01305c+carbon dioxide
Catalysed by PAICS
Reaction pageReversibleBalancedEC 4.1.1.21cytosol
Human-GEM MAR04804CC BY 4.0Reference data
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid+L-aspartate+ATPADP+proton+phosphate(3-)+(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate
6 names
Resolves to: PAICS
Catalysed by PAICS
Reaction pageLeft to rightBalancedEC 6.3.2.6cytosol
Human-GEM MAR04810CC BY 4.0Reference data
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate+hydron5-amino-1-(5-phospho-beta-D-ribosyl)imidazole+carbon dioxide
Catalysed by PAICS
Reaction pageRight to leftBalanced
Rhea RHEA:10792CC BY 4.0Reference data
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate+L-aspartate+ATP(4-)(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate+ADP(3-)+hydrogenphosphate+2hydron
Catalysed by PAICS
Reaction pageLeft to rightBalanced
Rhea RHEA:22628CC BY 4.0Reference data