2-oxohexanoate

1. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate

Catalysed by AGXT2

1. 2-oxohexanoate + L-kynurenine = L-2-aminohexanoate + kynurenate + H2O

Catalysed by AADAT

1. 2-oxohexanoate + L-kynurenine = L-2-aminohexanoate + kynurenate + H2O

Catalysed by AADATOne of 2 routes

1. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate
2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

Catalysed by AGXT2

1. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate
2. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

Catalysed by AGXT2

1. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate
2. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)

Catalysed by AGXT2, CSmitochondrial matrixOne of 2 routes

1. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate
2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
3. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)