1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

165 compounds within 3 steps: 8 in 1, 21 in 2, 136 in 3

One step

3-(methylthio)propionic acidReach from here →
1. acireductone dioxygenase
Catalysed by ADI1cytosol
formateReach from here →
1. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
Catalysed by ADI1One of 2 routes
4-methylsulfanyl-2-oxobutanoateReach from here →
1. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)
Catalysed by ADI1
COReach from here →
1. acireductone dioxygenase
Catalysed by ADI1cytosolOne of 2 routes
formic acidReach from here →
1. acireductone dioxygenase
Catalysed by ADI1cytosolOne of 2 routes
4-methylthio-2-oxobutanoic acidReach from here →
1. Acireductone Dixoygenase 1
Catalysed by ADI1cytosol
3-(methylsulfanyl)propanoateReach from here →
1. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
Catalysed by ADI1
5-methylsulfanyl-2,3-dioxopentyl phosphateReach from here →
1. 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate
Catalysed by ENOPH1

Two steps

2-hydroxybutyric acidReach from here →
1. acireductone dioxygenase
2. transport of 2-hydroxybutyrate and formate (cytosol to extracellular)
Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A7 and 1 morecytosol, extracellular spaceOne of 2 routes
acetoacetateReach from here →
1. acireductone dioxygenase
2. transport of acetoacetate and formate (cytosol to extracellular)
Catalysed by ADI1, SLC16A4, SLC16A5cytosol, extracellular space

Three steps

One of 2 routes

pyruvateReach from here →

Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, extracellular spaceOne of 2 routes

all-trans-retinoic acidReach from here →

Catalysed by ADI1, SLC16A4, SLC16A5cytosol, extracellular spaceOne of 2 routes

10-formyltetrahydrofolic acidReach from here →

Catalysed by ADI1, MTHFD1cytosolOne of 2 routes

methanethiolReach from here →

Catalysed by ADI1cytosol

formaldehydeReach from here →

Catalysed by ADI1, ALDH9A1

(R)-3-hydroxybutyric acidReach from here →

Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A7 and 1 morecytosol, extracellular spaceOne of 2 routes

(6R)-10-formyltetrahydrofolateReach from here →

Catalysed by ADI1, MTHFD1, MTHFD1L

chlorine(.)Reach from here →

Catalysed by ADI1, SLC26A4cytosol, extracellular spaceOne of 2 routes

acetateReach from here →

Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A1cytosol, extracellular spaceOne of 2 routes

oxalateReach from here →

Catalysed by ADI1, SLC26A6inner side of the membrane, outer side of the membraneOne of 2 routes

propionic acidReach from here →

Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A1cytosol, extracellular spaceOne of 2 routes

butyric acidReach from here →

Catalysed by ADI1, SLC16A4, SLC16A5cytosol, extracellular spaceOne of 2 routes

glyoxylateReach from here →

Catalysed by ADI1, AADAT

(S)-lactic acidReach from here →

Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

S-formylglutathioneReach from here →

Catalysed by ADI1, ESD

quercetinReach from here →

Catalysed by ADI1, PIRcytosol

L-methionineReach from here →

Catalysed by ADI1, TATcytosolOne of 4 routes

kynurenateReach from here →

Catalysed by ADI1, AADAT

N-formyl-L-kynurenineReach from here →

Catalysed by ADI1, AFMID

Catalysed by ADI1, SLC26A4, SLC6A14

cytosol, extracellular space

CHEBI:1146900Reach from here →

Catalysed by ADI1, TAT, NAGScytosol, mitochondrial matrix

prostaglandin E3Reach from here →

Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

prostaglandin A2Reach from here →

Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

prostaglandin J2Reach from here →

Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

all-trans-4-hydroxyretinoateReach from here →

Catalysed by ADI1, SLC16A4, SLC16A5, CYP26A1cytosol, extracellular spaceOne of 3 routes

N-acetylcadaverineReach from here →

Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A1 and 1 morecytosol, extracellular space

all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →

Catalysed by ADI1, SLC16A4, SLC16A5, UGT1A1 and 2 morecytosol, extracellular space, endoplasmic reticulum

all-trans-18-hydroxyretinoateReach from here →

Catalysed by ADI1, SLC16A4, SLC16A5, CYP1A1 and 24 morecytosol, extracellular spaceOne of 2 routes

a phenyl acetateReach from here →

Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A1 and 3 morecytosol, extracellular space

N-octanoyl-(2S)-hydroxyglycineReach from here →

Catalysed by ADI1, AADAT, PAM

N-decanoyl-(2S)-hydroxyglycineReach from here →

Catalysed by ADI1, AADAT, PAM

N-dodecanoyl-(2S)-hydroxyglycineReach from here →

Catalysed by ADI1, AADAT, PAM

N-tetradecanoyl-(2S)-hydroxyglycineReach from here →

Catalysed by ADI1, AADAT, PAM

N-(9Z-octadecenoyl)-(2S)-hydroxyglycineReach from here →

Catalysed by ADI1, AADAT, PAM

N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycineReach from here →

Catalysed by ADI1, AADAT, PAM

N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →

Catalysed by ADI1, MTHFD1, MTHFD1L, GART

CHEBI:15345Reach from here →

Catalysed by ADI1, SLC16A4, SLC16A5, AACScytosol, extracellular spaceOne of 3 routes

acetoneReach from here →

Catalysed by ADI1, SLC16A4, SLC16A5cytosol, extracellular space, mitochondrial matrix