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Proteins/UNIPROT:Q9BV57
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site (By similarity). Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line..
Function from UniProtKB (Q9BV57), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
488 statements
488 statements · 7 reference databases · Subject: ADI1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways · Rows fetched: 300
4 reactions
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one+dioxygen3-(methylthio)propionic acid+CO+formic acid+2proton
Catalysed by ADI1
Reaction pageLeft to rightBalancedEC 1.13.11.53cytosol
Human-GEM MAR05388CC BY 4.0Reference data
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one+dioxygen4-methylthio-2-oxobutanoic acid+formic acid
11 names
Resolves to: ADI1
Catalysed by ADI1
Reaction pageLeft to rightBalancedEC 1.13.11.54cytosol
Human-GEM MAR05389CC BY 4.0Reference data
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one+dioxygen3-(methylsulfanyl)propanoate+CO+formate+2hydron
Catalysed by ADI1
Reaction pageDirection not assertedBalanced
Rhea RHEA:14161CC BY 4.0Reference data
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one+dioxygen4-methylsulfanyl-2-oxobutanoate+formate+2hydron
Catalysed by ADI1
Reaction pageDirection not assertedBalanced
Rhea RHEA:24504CC BY 4.0Reference data