S-methylmercury-L-cysteine

Three steps

• palmitoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 11 routes

• oleoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by SLC7A8, NAGS, CPT1A, CPT1C and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Phenylacetate:CoA ligase

  Catalysed by SLC7A8, NAGSinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by SLC7A8, NAGS, ACSS3, ACSS2 and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 43 routes

• CHEBI:15570Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by SLC7A8, SLC7A5, SLC3A2, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 5 routes

• CHEBI:15611Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by SLC7A8, SLC7A5, GNMTinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:15650Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by SLC7A8, NAGS, ZDHHC11B, NAA10 and 30 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• trimethylenediamineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of lysine and methionine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by SLC7A8, SLC7A6, DHPSinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:15727Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by SLC7A8, NAGS, NAA10inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:15746Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by SLC7A8, NAGS, SAT1, SAT2inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by SLC7A8, SLC7A13, CADinner side of the membrane, outer side of the membrane, cytosol

• alpha-D-glucosamine 6-phosphateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by SLC7A8, SLC7A5, GFPT2, GFPT1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• thioredoxin dithiolReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. L-Methionine:tRNAMet ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by SLC7A8, MARS1inner side of the membrane, outer side of the membrane, cytosolOne of 4 routes

• sulfateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by SLC7A8, SLC6A14, SLC26A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• ureaReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of arginine and methionine (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by SLC7A8, SLC7A6, ARG1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• 11-cis-retinolReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by SLC7A8, NAGS, DGAT1, LRAT and 3 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• cob(II)alaminReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2

  Catalysed by SLC7A8, CDKAL1, MTRRinner side of the membrane, outer side of the membrane

• (R)-3-aminoisobutyric acidReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of alanine and methionine (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC7A8, SLC7A5, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• iodideReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of methionine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by SLC7A8, SLC7A5, TPOinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 25 routes

• 2-phenylacetaldehydeReach from here →
  1. S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)
  2. L-phenylalanine carboxy-lyase (phenylethylamine-forming)
  3. Phenethylamine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC7A8, DDC, AOC2, AOC1 and 3 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• oxaloacetateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. ATP citrate lyase (citrate)

  Catalysed by SLC7A8, NAGS, ACLYinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 6 routes

• nitric oxideReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of arginine and methionine (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by SLC7A8, SLC7A6, NOS3, NOS1 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• CHEBI:16523Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SLC7A8, SLC7A5, SLC3A2, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by SLC7A8, SLC7A6, ACY1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• anthranilateReach from here →
  1. S-methylmercury-L-cysteine(in) + L-leucine(out) = S-methylmercury-L-cysteine(out) + L-leucine(in)
  2. Transport of L-Kynurenine
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by SLC7A8, SLC43A1, KYNUinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:16633Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of alanine and methionine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC7A8, SLC7A5, SCLYinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• (S)-lactateReach from here →
  1. S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)
  2. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SLC7A8, CNDP2inner side of the membrane, outer side of the membrane

• 3'-deoxy-3',4'-didehydro-CTPReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

  Catalysed by SLC7A8, CDKAL1, RSAD2inner side of the membrane, outer side of the membrane

• 2-oxobutanoateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of methionine and threonine (cytosol to extracellular)
  3. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by SLC7A8, SLC7A5, SDS, SDSLinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• tryptamineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by SLC7A8, SLC7A5, DDCinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by SLC7A8, SLC7A5, KYAT1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• (S)-2-hydroxyglutarateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2

  Catalysed by SLC7A8, CDKAL1, L2HGDHinner side of the membrane, outer side of the membrane

• enol-phenylpyruvateReach from here →
  1. S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)
  2. Phenylalanine Transaminase, Mitochondrial
  3. 3-phenylpyruvate = enol-phenylpyruvate

  Catalysed by SLC7A8, GOT2, TAT, MIFinner side of the membrane, outer side of the membrane, mitochondrial matrix

• CHEBI:16856Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by SLC7A8, SLC7A5, GSSinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• glyoxylic acidReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC7A8, SLC7A5, DAOinner side of the membrane, outer side of the membrane, extracellular space, cytosol, peroxisome

• N-acetyl-L-aspartateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by SLC7A8, SLC7A13, NAT8Linner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• oxalic acidReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by SLC7A8, SLC6A14, SLC26A6inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• L-glutamic 5-semialdehydeReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by SLC7A8, SLC7A6, OATinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• anilineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by SLC7A8, NAGS, NAT2, NAT1inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• CHEBI:17312Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by SLC7A8, NAGSinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by SLC7A8, CDKAL1, CDK5RAP1inner side of the membrane, outer side of the membraneOne of 4 routes

• CHEBI:17380Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by SLC7A8, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of methionine and proline (cytosol to extracellular)
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by SLC7A8, SLC7A5, PRODH2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• agmatineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of arginine and methionine (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by SLC7A8, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• 5-aminolevulinic acidReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by SLC7A8, SLC7A5, ALAS1, ALAS2 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• indole-3-pyruvateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by SLC7A8, SLC7A5, IL4I1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 3,3',5'-triiodo-L-thyronine sulfateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2

  Catalysed by SLC7A8, CDKAL1, DIO1inner side of the membrane, outer side of the membrane

• 3,3'-diiodo-L-thyronineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2

  Catalysed by SLC7A8, CDKAL1, DIO1, DIO3inner side of the membrane, outer side of the membraneOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2

  Catalysed by SLC7A8, CDKAL1, DIO1inner side of the membrane, outer side of the membraneOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by SLC7A8, NAGS, HADHA, ACADVL and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix