3-phenylpyruvate

Three steps

• glycyldehydrophenylalanineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by GOT2, TAT, SLC7A5, DPEP1mitochondrial matrix, extracellular space, cytosol

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by GOT2, TAT, SLC7A5, PFASmitochondrial matrix, extracellular space, cytosol

• kinetensin-(1-8)Reach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. Chymase
  3. kinetensin + H2O = kinetensin-(1-8) + L-leucine

  Catalysed by GOT2, TAT, CMA1, ACE2mitochondrial matrix, extracellular space

• an N-(fatty acyl)-glycineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by GOT2, TAT, SLC7A5, GLYATL2mitochondrial matrix, extracellular space, cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by GOT2, TAT, SLC7A5, GLYATL2mitochondrial matrix, extracellular space, cytosol

• acetaldehydeReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of phenylalanine and threonine (cytosol to extracellular)
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by GOT2, TAT, SLC7A5mitochondrial matrix, extracellular space, cytosol

• cholineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. transport of chloride and choline (cytosol to extracellular)

  Catalysed by GOT2, TAT, SLC6A14, SLC5A7mitochondrial matrix, extracellular space, cytosol

• acetylpyruvateReach from here →
  1. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by AADAT, AGXT, AGXT2, FAHD1

• all-trans-retinoic acidReach from here →
  1. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. transport of pyruvate and retinoate (cytosol to extracellular)

  Catalysed by AADAT, AGXT, AGXT2, SLC16A4 and 5 moreextracellular space, cytosolOne of 2 routes

• propionyl-CoAReach from here →
  1. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. 2-oxobutyrate oxidation

  Catalysed by AADAT, AGXT2cytosol

• CHEBI:15570Reach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by GOT2, TAT, SLC7A5, SLC3A2 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 5 routes

• CHEBI:15611Reach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by GOT2, TAT, SLC7A5, GNMTmitochondrial matrix, extracellular space, cytosol

• trimethylenediamineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of lysine and phenylalanine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by GOT2, TAT, SLC7A6, DHPSmitochondrial matrix, extracellular space, cytosol

• CHEBI:15727Reach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of histidine and phenylalanine (cytosol to extracellular)
  3. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by GOT2, TAT, SLC7A6, CARNS1mitochondrial matrix, extracellular space, cytosol

• formateReach from here →
  1. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  2. glyoxylate + O2 + H2O = oxalate + H2O2 + H(+)
  3. oxalate(in) + formate(out) = oxalate(out) + formate(in)

  Catalysed by AADAT, HAO1, SLC26A6inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:15765Reach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of phenylalanine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by GOT2, TAT, SLC7A5, THmitochondrial matrix, extracellular space, cytosolOne of 5 routes

• malonateReach from here →
  1. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)

  Catalysed by AADAT, CLYBL, SLC25A10inner side of the membrane, outer side of the membraneOne of 2 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by GOT2, TAT, SLC7A13, CADmitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosol

• alpha-D-glucosamine 6-phosphateReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by GOT2, TAT, SLC7A5, GFPT2 and 1 moremitochondrial matrix, extracellular space, cytosol

• thioredoxin dithiolReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by GOT2, TAT, FARSB, FARSAmitochondrial matrix, cytosolOne of 2 routes

• homogentisateReach from here →
  1. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. 4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)

  Catalysed by AADAT, HPDcytosolOne of 2 routes

• sulfateReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by GOT2, TAT, SLC6A14, SLC26A6mitochondrial matrix, extracellular space, cytosolOne of 11 routes

• ureaReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by GOT2, TAT, SLC7A6, ARG1mitochondrial matrix, extracellular space, cytosolOne of 3 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by AADAT, AGXT, AGXT2mitochondrial matrix

• L-cystineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by GOT2, TAT, SLC7A5, SLC7A9 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 9 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by GOT2, TAT, SLC7A5, AGXT2mitochondrial matrix, extracellular space, cytosol

• (R)-carnitineReach from here →
  1. 3-phenylpyruvate + L-kynurenine = kynurenate + L-phenylalanine + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)

  Catalysed by AADAT, SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• iodideReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of phenylalanine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by GOT2, TAT, SLC7A5, TPOmitochondrial matrix, extracellular space, cytosolOne of 3 routes

• 2-phenylacetaldehydeReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. L-phenylalanine carboxy-lyase (phenylethylamine-forming)
  3. Phenethylamine:oxygen oxidoreductase (deaminating)

  Catalysed by GOT2, TAT, DDC, AOC2 and 4 moremitochondrial matrix, cytosolOne of 2 routes

• oxaloacetateReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. L-Aspartate:2-oxoglutarate aminotransferase

  Catalysed by GOT2, TAT, SLC7A13mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 14 routes

• nitric oxideReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by GOT2, TAT, SLC7A6, NOS3 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by GOT2, TAT, SLC7A5, SLC3A2 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by GOT2, TAT, SLC7A6, ACY1mitochondrial matrix, extracellular space, cytosol

• anthranilateReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. Transport of L-Kynurenine
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by GOT2, TAT, SLC7A8, KYNUmitochondrial matrix, extracellular space, cytosol

• CHEBI:16633Reach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by GOT2, TAT, SLC7A5, SCLYmitochondrial matrix, extracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by GOT2, TAT, SLC7A5, MARS1mitochondrial matrix, extracellular space, cytosol

• (S)-lactateReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by GOT2, TAT, CNDP2mitochondrial matrixOne of 2 routes

• tryptamineReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by GOT2, TAT, SLC7A5, DDCmitochondrial matrix, extracellular space, cytosol

• 3-fumarylpyruvateReach from here →
  1. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by AADAT, AGXT, AGXT2, FAHD1

• CHEBI:16856Reach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by GOT2, TAT, SLC7A5, GSSmitochondrial matrix, extracellular space, cytosolOne of 2 routes

• glyoxylic acidReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by GOT2, TAT, SLC7A5, DAOmitochondrial matrix, extracellular space, cytosol, peroxisomeOne of 4 routes

• N-acetyl-L-aspartateReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by GOT2, TAT, SLC7A13, NAT8Lmitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• oxalic acidReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by GOT2, TAT, SLC6A14, SLC26A6mitochondrial matrix, extracellular space, cytosol

• (R)-3-hydroxybutyric acidReach from here →
  1. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by AADAT, AGXT, AGXT2, SLC16A4 and 5 moreextracellular space, cytosolOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by AADAT, AGXT, AGXT2

• (S)-4-hydroxymandelateReach from here →
  1. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. 3-(4-hydroxyphenyl)pyruvate + O2 = (S)-4-hydroxymandelate + CO2

  Catalysed by AADAT, HPDL

• L-glutamic 5-semialdehydeReach from here →
  1. Phenylalanine Transaminase, Mitochondrial
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by GOT2, TAT, SLC7A6, OATmitochondrial matrix, extracellular space, cytosol

• itaconateReach from here →
  1. 3-phenylpyruvate + L-kynurenine = kynurenate + L-phenylalanine + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate

  Catalysed by AADAT, SLC22A6, SUGCTinner side of the membrane, outer side of the membrane

• aceneuramateReach from here →
  1. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by AADAT, AGXT, AGXT2, NPL

• 5'-deoxyadenosineReach from here →
  1. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by AADAT, AGXT, AGXT2, TYW1B and 1 more