sulfite

Three steps

• androsteroneReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. steroid sulfatase (androsterone sulfate)
  3. steroid sulfatase (androsterone sulfate)

  Catalysed by SUOX, STSmitochondrial matrix, cytosolOne of 3 routes

• CHEBI:16174Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. pyruvate kinase (dTDP)
  3. nucleoside-diphosphate kinase (dADP)

  Catalysed by MPST, TST, PKM, PKLR and 6 morecytosolOne of 3 routes

• ureaReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. Peroxidase

  Catalysed by TSTD1, SLC22A13, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 3 routes

• dimethylarsinateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  3. methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by TSTD1, GSTO1, GSTO2, HEMK2

• L-cystineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. cystine to cysteine conversion

  Catalysed by MPST, TST, TSTD1cytosolOne of 4 routes

• CHEBI:16284Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. pyruvate kinase (dTDP)
  3. deoxythymidylate kinase (dADP)

  Catalysed by MPST, TST, PKM, PKLR and 1 morecytosol, mitochondrial matrixOne of 3 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (S)-3-amino-2-methylpropionate transaminase (2-methyl-3-oxopropanoate)

  Catalysed by MPST, TST, AGXT2, ABATcytosol, mitochondrial matrixOne of 3 routes

• lithocholic acidReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. transport of GSH and lithocholate (cytosol to extracellular)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• 17beta-hydroxy-5alpha-androstan-3-oneReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. steroid sulfatase (5-alpha-dihydrotestosterone)
  3. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by SUOX, STSmitochondrial matrix, cytosolOne of 3 routes

• L-citrullineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and citrulline (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 5 routes

• iodideReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by SUOX, SLC26A6, SLC26A4mitochondrial matrix, cytosol, extracellular space

• cis-aconitateReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. Citrate Transport, Mitochondrial
  3. cis-aconitate(in) + citrate(out) = cis-aconitate(out) + citrate(in)

  Catalysed by SLC25A10, SLC25A1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-valineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and valine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 13 routes

• L-arginineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and arginine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 12 routes

• CHEBI:16497Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. pyruvate kinase (dTDP)
  3. dGTP:pyruvate 2-O-phosphotransferase

  Catalysed by MPST, TST, PKM, PKLRcytosol

• protein polypeptide chainReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. PROTEIN_BS

  Catalysed by MPST, TST, AGXT2cytosol, mitochondrial matrixOne of 3 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• pregnenoloneReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. Steryl-Sulfatase
  3. Pregnenolone-sulfate sulfohydrolase

  Catalysed by SUOX, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 4 routes

• CHEBI:16633Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by MPST, TST, AGXT2, SCLYcytosol, mitochondrial matrix

• Met-tRNA(Met)Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by MPST, TST, TYW1B, TYW1 and 1 morecytosol

• (R)-glycerateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. L-Serine:pyruvate aminotransferase
  3. D-glycerate:NADP+ 2-oxidoreductase

  Catalysed by MPST, TST, AGXT, GRHPRcytosolOne of 4 routes

• taurochenodeoxycholate 3-sulfateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. taurochenodeoxycholate + 3'-phosphoadenylyl sulfate = taurochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by TSTD1, ABCC4, SULT2A1inner side of the membrane, outer side of the membrane

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by MPST, TST, TYW1B, TYW1 and 1 morecytosolOne of 2 routes

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by MPST, TST, LDHA, LDHB and 4 morecytosol

• formaldehydeReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. S-formylglutathione + H2O = formate + glutathione + H(+)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by TSTD1, ESD, ADH1C, ADH1A and 4 morecytosol

• CHEBI:16857Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and threonine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 8 routes

• N-acetyl-L-aspartateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by SUOX, SLC25A14, SLC25A30, NAT8Lmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• bilirubin IXalphaReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. transport of bilirubin and GSH (cytosol to extracellular)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• glycolaldehydeReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. L-Serine:pyruvate aminotransferase
  3. hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)

  Catalysed by MPST, TST, AGXTcytosolOne of 2 routes

• 4-maleylacetoacetateReach from here →
  1. transport of fumarate and sulfite (cytosol to mitochondria)
  2. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)
  3. 4-maleylacetoacetate = 4-fumarylacetoacetate

  Catalysed by SLC25A10, FAH, GSTZ1mitochondrial matrix, cytosol

• aldehydo-N-acetyl-D-mannosamineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by MPST, TST, NPLcytosolOne of 2 routes

• (R)-lactaldehydeReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (R)-S-lactoylglutathione = methylglyoxal + glutathione
  3. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)

  Catalysed by TSTD1, GLO1, ADH1C, ADH1A and 5 morecytosol

• taurolithocholateReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. transport of GSH and taurolithocholate (cytosol to extracellular)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• L-isoleucineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and isoleucine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 8 routes

• CHEBI:17203Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and proline (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 9 routes

• CHEBI:17208Reach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. glutathione:dehydroascorbate oxidoreductase

  Catalysed by ETHE1mitochondrial matrix, cytosolOne of 2 routes

• homocysteineReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. Formation of Homocystine

  Catalysed by ETHE1mitochondrial matrix, cytosol

• itaconateReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  3. cis-aconitate carboxy-lyase

  Catalysed by SLC25A10, SLC25A1, ACOD1mitochondrial matrix, cytosol

• 17alpha-hydroxyprogesteroneReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space, endoplasmic reticulum

• estroneReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. estrone 3-sulfate + H2O = estrone + sulfate + H(+)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by SUOX, STSmitochondrial matrix, cytosolOne of 3 routes

• propanoateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by SUOX, STS, SLC22A9mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. transport of fumarate and sulfite (cytosol to mitochondria)
  2. a quinone + succinate = fumarate + a quinol
  3. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)

  Catalysed by SLC25A10, SDHB, PRODH, PRODH2mitochondrial matrix, cytosol

• AH2Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by MPST, TST, AGXT2, MOCOScytosol, mitochondrial matrixOne of 7 routes

• L-cysteineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)

  Catalysed by MPST, TST, CBScytosolOne of 28 routes

• indole-3-pyruvateReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine

  Catalysed by SLC25A10, CLYBL, AADATmitochondrial matrix, cytosol

• 3,3'-diiodo-L-thyronineReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. Steryl-Sulfatase
  3. Steryl-Sulfatase

  Catalysed by SUOX, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 3 routes

• xanthineReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. xanthine + NAD(+) + H2O = urate + NADH + H(+)

  Catalysed by TSTD1, SLC22A13, XDHinner side of the membrane, outer side of the membraneOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by MPST, TST, AGXT2, AARS1cytosol, mitochondrial matrix

• glycine betaineReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SUOX, SLC26A6, SLC6A12mitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• 4-methylumbelliferyl acetateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 6 morecytosol, extracellular space