L-arginine

Two steps

• 5-aminolevulinic acidReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by SLC7A6, ALAS1, ALAS2, CPNE7extracellular space, cytosol, mitochondrial matrix

• nitrateReach from here →
  1. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)
  2. Fe(II)-heme b-[protein] + nitric oxide + O2 = Fe(III)-heme b-[protein] + nitrate

  Catalysed by NOS3, NOS1, NOS2, CYGBcytosol

• indole-3-pyruvateReach from here →
  1. transport of arginine and tryptophan (cytosol to extracellular)
  2. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by SLC7A6, IL4I1extracellular space, cytosolOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC7A6, AARS1extracellular space, cytosol

• glycine betaineReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SLC6A14, SLC6A12extracellular space, cytosolOne of 3 routes

• CHEBI:17769Reach from here →
  1. Putrescine Export via Putrescine/Arginine Antiporter
  2. Putrescine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC3A2, SLC7A7, AOC2, AOC1 and 1 moreextracellular space, cytosolOne of 2 routes

• trans-urocanateReach from here →
  1. transport of arginine and histidine (cytosol to extracellular)
  2. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by SLC7A5, SLC7A6, HALextracellular space, cytosolOne of 2 routes

• urateReach from here →
  1. L-Arginine amidinohydrolase
  2. Peroxidase

  Catalysed by ARG1, MPOcytosol, nucleusOne of 3 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. transport of arginine and tryptophan (cytosol to extracellular)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC7A6, TPH1, TPH2extracellular space, cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. transport of arginine and leucine (cytosol to extracellular)
  2. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC3A2, SLC7A6, SLC7A7, BCAT2extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• 3-phenylpyruvateReach from here →
  1. transport of arginine and phenylalanine (cytosol to extracellular)
  2. Phenylalanine Transaminase, Mitochondrial

  Catalysed by SLC7A6, GOT2, TATextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• fumaric acidReach from here →
  1. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
  2. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by ASLcytosolOne of 2 routes

• CHEBI:18095Reach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. Transport of Hydroxy-Proline

  Catalysed by SLC7A6, SLC1A4extracellular space, cytosolOne of 5 routes

• N-carbamoyl-beta-alanineReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. Transport of 3-Ureidopropionate

  Catalysed by SLC6A14extracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by SLC7A6, GARTextracellular space, cytosol

• 2-phenylethylamineReach from here →
  1. transport of arginine and phenylalanine (cytosol to extracellular)
  2. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by SLC7A6, DDCextracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. transport of arginine and glutamine (cytosol to extracellular)
  2. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by SLC7A6, PFASextracellular space, cytosol

• ophthalmateReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by SLC7A6, GSSextracellular space, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. transport of arginine and methionine (cytosol to extracellular)
  2. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by SLC7A6, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SLC7A6, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• biocytinReach from here →
  1. L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)
  2. biocytin + H2O = biotin + L-lysine

  Catalysed by SLC7A9, SLC25A29, SLC7A6, BTDinner side of the membrane, outer side of the membrane

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. N(omega),N(omega)-dimethyl-L-arginine(in) + L-arginine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-arginine(in)
  2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC25A2, AGXT2inner side of the membrane, outer side of the membraneOne of 6 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC7A6, AGXT2extracellular space, cytosolOne of 2 routes

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. N(omega)-methyl-L-arginine(in) + L-arginine(out) = N(omega)-methyl-L-arginine(out) + L-arginine(in)
  2. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC25A29, AGXT2inner side of the membrane, outer side of the membraneOne of 2 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SLC7A6, SHMT1extracellular space, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. transport of arginine and cysteine (cytosol to extracellular)
  2. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by SLC7A6, CARS2extracellular space, cytosol

• CHEBI:240943Reach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLC7A6, GLYAT, GLYATL2, GLYATL1extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• hypochlorous acidReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. Peroxidase

  Catalysed by SLC6A14, LPOextracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)

  Catalysed by SLC6A14, SLC12A2, SLC12A1extracellular space, cytosolOne of 2 routes

• phenylacetylglycineReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by SLC7A6, GLYATextracellular space, cytosolOne of 3 routes

• 5-hydroxytryptophanReach from here →
  1. transport of arginine and tryptophan (cytosol to extracellular)
  2. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by SLC7A6, TPH1, TPH2extracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. LTD4 hydrolysis

  Catalysed by SLC7A6extracellular space, cytosol

• pyridoxine 5'-phosphateReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC7A6, SCLYextracellular space, cytosol

• 3-disulfanyl-L-alanineReach from here →
  1. L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)
  2. L-cystine thiocysteine-lyase (deaminating

  Catalysed by SLC7A9, CTHinner side of the membrane, outer side of the membrane, cytosol

• N-acetyl-L-cysteineReach from here →
  1. transport of arginine and cysteine (cytosol to extracellular)
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SLC7A6, NAGSextracellular space, cytosol, mitochondrial matrix

• K(+)Reach from here →
  1. transport of arginine and cysteine (cytosol to extracellular)
  2. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC7A6, SLC1A1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• Cys-tRNA(Cys)Reach from here →
  1. transport of arginine and cysteine (cytosol to extracellular)
  2. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by SLC7A6, CARS1extracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. transport of arginine and phenylalanine (cytosol to extracellular)
  2. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC7A6, FARSB, FARSAextracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by SLC7A6, GARS1extracellular space, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. transport of arginine and tryptophan (cytosol to extracellular)
  2. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by SLC7A6, WARS1extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. transport of arginine and isoleucine (cytosol to extracellular)
  2. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by SLC7A6, IARS1extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. transport of arginine and glutamine (cytosol to extracellular)
  2. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by SLC7A6, QARS1extracellular space, cytosol

• isocyanateReach from here →
  1. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)
  2. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by NOS3, NOS1, NOS2, LACC1cytosol

• Asn-tRNA(Asn)Reach from here →
  1. transport of arginine and asparagine (cytosol to extracellular)
  2. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by SLC7A6, NARS1extracellular space, cytosol

• glycocholateReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC7A6, BAATextracellular space, cytosol, peroxisomeOne of 3 routes

• hydrogen sulfideReach from here →
  1. transport of arginine and cysteine (cytosol to extracellular)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by SLC7A6, CTHextracellular space, cytosolOne of 2 routes

• L-aspartateReach from here →
  1. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
  2. L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)

  Catalysed by ASL, ASS1cytosolOne of 22 routes

• CHEBI:30249Reach from here →
  1. transport of arginine and tryptophan (cytosol to extracellular)
  2. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by SLC7A6, IDO1, TDO2, IDO2extracellular space, cytosol

• 3-acetamidopropanalReach from here →
  1. Transport by Y+Lat-2 into Extracellular Space
  2. N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming)

  Catalysed by SLC3A2, SLC7A6, PAOX, SMOXextracellular space, cytosolOne of 2 routes

• formic acidReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)

  Catalysed by SLC6A14, SLC26A4extracellular space, cytosolOne of 2 routes