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3-acetamidopropanal

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

21 compounds within 3 steps: 3 in 1, 4 in 2, 14 in 3

Does it reach a compound?

One step

N(1)-acetylspermineReach from here →
1. N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2
Catalysed by PAOX
N(1)-acetylspermidineReach from here →
1. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
Catalysed by PAOX
N(1),N(12)-diacetylspermineReach from here →
1. N(1),N(12)-diacetylspermine + O2 + H2O = 3-acetamidopropanal + N(1)-acetylspermidine + H2O2
Catalysed by PAOX

Two steps

CHEBI:17312Reach from here →
1. N(1),N(12)-diacetylspermine + O2 + H2O = 3-acetamidopropanal + N(1)-acetylspermidine + H2O2
2. N1,N12-diacetylspermine to N1-acetylspermine conversion
Catalysed by PAOXcytosolOne of 2 routes
CHEBI:17927Reach from here →
1. N(1),N(12)-diacetylspermine + O2 + H2O = 3-acetamidopropanal + N(1)-acetylspermidine + H2O2
2. N(1)-acetylpolyamine oxidase (N1,N12-diacetylspermine)
Catalysed by PAOX, SMOXcytosolOne of 2 routes
putrescineReach from here →

Three steps

CHEBI:1146900Reach from here →
Catalysed by PAOX, SAT1, SAT2cytosolOne of 7 routes
trimethylenediamineReach from here →
Catalysed by

N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2

N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2

Catalysed by PAOX

spermidineReach from here →

N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2
N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2

Catalysed by PAOX

cytosol

One of 2 routes

CHEBI:15746Reach from here →

N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2
N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2
S-adenosylmethioninamine:spermidine 3-aminopropyltransferase

Catalysed by PAOX, SRM, SMScytosolOne of 3 routes

L-arginineReach from here →

N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
Putrescine Export via Putrescine/Arginine Antiporter

Catalysed by PAOX, SLC3A2, SLC7A7extracellular space, cytosolOne of 2 routes

S-methyl-5'-thioadenosineReach from here →

N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2
N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2
S-adenosylmethioninamine:spermidine 3-aminopropyltransferase

Catalysed by PAOX, SRM, SMScytosolOne of 4 routes

CHEBI:17769Reach from here →

N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2
N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2
spermidine:(acceptor) oxidoreductase

Catalysed by PAOXcytosolOne of 3 routes

N-(4-aminobutyl)-3-aminopropanalReach from here →

N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2
N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2
primary-amine oxidase (spermidine)

Catalysed by PAOX, AOC2, AOC1, AOC3cytosolOne of 3 routes

spermineReach from here →

N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2
N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2
S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = spermine + S-methyl-5'-thioadenosine + H(+)

Catalysed by PAOX, SMSOne of 2 routes

L-ornithineReach from here →

N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
L-ornithine + H(+) = putrescine + CO2

Catalysed by PAOX, ODC1

S-adenosyl 3-(methylsulfanyl)propylamineReach from here →

N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2
N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2
S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)

Catalysed by PAOX, SRM

propane-1,3-diamineReach from here →

N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2
N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2
[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine

Catalysed by PAOX, DHPS

N-acetylputrescineReach from here →

N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
acetyl-CoA:putrescine N-acetyltransferase

Catalysed by PAOX, SAT1, SAT2cytosolOne of 2 routes

4-aminobutanalReach from here →

N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
putrescine + O2 + H2O = 4-aminobutanal + H2O2 + NH4(+)

Catalysed by PAOX, AOC1

N(8)-acetylspermidineReach from here →

N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2
N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2
N8-acetylspermidine to spermidine conversion

Catalysed by PAOXcytosolOne of 3 routes