Loading the page.
Proteins/UNIPROT:Q9NWM0
Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.
Function from UniProtKB (Q9NWM0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
42 statements
42 statements · 4 reference databases · Subject: SMOX · Sources: Hetionet, Human-GEM, Rhea, UniProt
8 reactions
water+dioxygen+CHEBI:157463-aminopropanal+hydrogen peroxide+spermidine
Catalysed by SMOX
Reaction pageLeft to rightBalancedEC 1.5.3.17cytosol
Human-GEM MAR04078CC BY 4.0Reference data
water+CHEBI:17312+dioxygen3-acetamidopropanal+hydrogen peroxide+
5 names
Resolves to: SMOX
Reaction pageLeft to rightBalancedEC 1.5.3.13, 1.5.3.16cytosol
Human-GEM MAR06958CC BY 4.0Reference data
FAD+water+CHEBI:173123-acetamidopropanal+FADH2+spermidine
Reaction pageLeft to rightBalancedEC 1.5.3.13, 1.5.3.16peroxisome
Human-GEM MAR06959CC BY 4.0Reference data
water+CHEBI:17927+dioxygen3-acetamidopropanal+hydrogen peroxide+putrescine
Reaction pageLeft to rightBalancedEC 1.5.3.13, 1.5.3.16cytosol
Human-GEM MAR06961CC BY 4.0Reference data
FAD+water+CHEBI:179273-acetamidopropanal+FADH2+putrescine
Reaction pageLeft to rightBalancedEC 1.5.3.13, 1.5.3.16peroxisome
Human-GEM MAR06962CC BY 4.0Reference data
water+N(1),N(12)-diacetylspermine+dioxygen3-acetamidopropanal+hydrogen peroxide+CHEBI:17927
Reaction pageLeft to rightBalancedEC 1.5.3.13, 1.5.3.16cytosol
Human-GEM MAR06963CC BY 4.0Reference data
FAD+water+N(1),N(12)-diacetylspermine3-acetamidopropanal+FADH2+CHEBI:17927
Reaction pageLeft to rightBalancedEC 1.5.3.13, 1.5.3.16peroxisome
Human-GEM MAR06964CC BY 4.0Reference data
spermine+dioxygen+water3-aminopropanal+spermidine+hydrogen peroxide
Catalysed by SMOX
Reaction pageDirection not assertedBalanced
Rhea RHEA:25804CC BY 4.0Reference data