Loading the page.
Proteins/UNIPROT:P43005
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity)..
Function from UniProtKB (P43005), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 3 · transported by
3 compounds
3 compounds.
0 reported routes3 assembled routes
2 rows
115 statements
115 statements · 8 reference databases · Subject: SLC1A1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
9 reactions
L-glutamate(1-)+proton+potassium atom+3sodium(1+)L-glutamate(1-)+proton+potassium atom+3sodium(1+)
Transported by SLC1A3 or SLC1A6 or SLC1A1 or SLC1A2 or SLC1A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04932CC BY 4.0Reference data
7 names
Resolves to: SLC1A1
L-aspartate+sodium(1+)L-aspartate+sodium(1+)
Transported by SLC1A3 or SLC1A6 or SLC1A1 or SLC1A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05328CC BY 4.0Reference data
L-glutamate(1-)+sodium(1+)L-glutamate(1-)+sodium(1+)
Transported by SLC1A3 or SLC1A6 or SLC1A1 or SLC1A2 or SLC1A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05330CC BY 4.0Reference data
L-aspartate+proton+potassium atom+3sodium(1+)L-aspartate+proton+potassium atom+3sodium(1+)
Transported by SLC1A3 or SLC1A6 or SLC1A1 or SLC1A2 or SLC1A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05447CC BY 4.0Reference data
D-aspartic acid+proton+potassium atom+3sodium(1+)D-aspartic acid+proton+potassium atom+3sodium(1+)
Transported by SLC1A3 or SLC1A6 or SLC1A1 or SLC1A2 or SLC1A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR07639CC BY 4.0Reference data
K(+)+L-glutamate(1-)+3sodium(1+)+hydronK(+)+L-glutamate(1-)+3sodium(1+)+hydron
Transported by SLC1A7 or SLC1A3 or SLC1A2 or SLC1A1 or SLC1A6
Reaction pageDirection not assertedBalanced
Rhea RHEA:70699CC BY 4.0Reference data
K(+)+L-aspartate+3sodium(1+)+hydronK(+)+L-aspartate+3sodium(1+)+hydron
Transported by SLC1A7 or SLC1A3 or SLC1A2 or SLC1A1 or SLC1A6
Reaction pageDirection not assertedBalanced
Rhea RHEA:70851CC BY 4.0Reference data
D-aspartate+K(+)+3sodium(1+)+hydronD-aspartate+K(+)+3sodium(1+)+hydron
Transported by SLC1A7 or SLC1A3 or SLC1A2 or SLC1A1 or SLC1A6
Reaction pageDirection not assertedBalanced
Rhea RHEA:71379CC BY 4.0Reference data
K(+)+L-cysteine+3sodium(1+)+hydronK(+)+L-cysteine+3sodium(1+)+hydron
Transported by SLC1A1
Reaction pageDirection not assertedBalanced
Rhea RHEA:82559CC BY 4.0Reference data