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CHEBI:28666

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

557 compounds within 3 steps: 5 in 1, 119 in 2, 433 in 3

Does it reach a compound?

One step

2,4-dinitrophenyl-S-glutathioneReach from here →
1. transport of LTD4 (cytosol to extracellular)
Catalysed by SLCO1B1extracellular space, cytosolOne of 2 routes
CHEBI:15650Reach from here →
1. membrane dipeptidase (LTD4)
Catalysed by DPEP1, DPEP2extracellular spaceOne of 2 routes
CHEBI:16856Reach from here →
1. transport of GSH and LTD4 (cytosol to extracellular)
Catalysed by SLCO2A1extracellular space, cytosolOne of 2 routes
glycineReach from here →
1. membrane dipeptidase (LTD4)
Catalysed by DPEP1, DPEP2extracellular spaceOne of 2 routes
leukotriene C4Reach from here →
1. leukotriene-C4 hydrolase
Catalysed by GGT1, GGT5, GGTLC2, GGT6 and 2 moreendoplasmic reticulum

Two steps

CHEBI:1146900Reach from here →
1. membrane dipeptidase (LTD4)
2. bile acid-CoA: amino acid N-acyltransferase
Catalysed by DPEP1, DPEP2, BAATextracellular space, peroxisomeOne of 30 routes
N(omega)-methyl-L-arginineReach from here →
1. membrane dipeptidase (LTD4)
2. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine
Catalysed by DPEP1, DPEP2, AGXT2extracellular space

Page 1 of 12

tauroursodeoxycholate

Reach from here →

transport of LTD4 (cytosol to extracellular)
transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

glycoursodeoxycholateReach from here →

membrane dipeptidase (LTD4)
glycine to glycoursodeoxycholate conversion

Catalysed by DPEP1, DPEP2extracellular space, cytosolOne of 6 routes

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →

transport of GSH and LTD4 (cytosol to extracellular)
glutathione transferase (GSH)

Catalysed by SLCO2A1, PTGES, MGST3, GSTA4 and 18 moreextracellular space, cytosolOne of 4 routes

prostaglandin E3Reach from here →

transport of LTD4 (cytosol to extracellular)
transport of prostaglandin E3 (cytosol to extracellular)

Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

prostaglandin A2Reach from here →

transport of LTD4 (cytosol to extracellular)
transport of prostaglandin A2 (cytosol to extracellular)

Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

prostaglandin B1Reach from here →

transport of LTD4 (cytosol to extracellular)
transport of prostaglandin B1 (cytosol to extracellular)

Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

leukotriene F4Reach from here →

membrane dipeptidase (LTD4)
leukotriene F4 hydrolysis

Catalysed by DPEP1, DPEP2extracellular space, cytosolOne of 7 routes

N-(9Z-octadecenoyl)glycineReach from here →

membrane dipeptidase (LTD4)
(9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

Catalysed by DPEP1, DPEP2, GLYATL3, GLYATL2extracellular space

N-octadecanoylglycineReach from here →

membrane dipeptidase (LTD4)
octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

Catalysed by DPEP1, DPEP2, GLYATL2extracellular space

N-(9Z-hexadecenoyl)-glycineReach from here →

membrane dipeptidase (LTD4)
(9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

Catalysed by DPEP1, DPEP2, GLYATL2extracellular space

N-hexadecanoylglycineReach from here →

membrane dipeptidase (LTD4)
hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

Catalysed by DPEP1, DPEP2, GLYATL3extracellular space

N-dodecanoylglycineReach from here →

membrane dipeptidase (LTD4)
dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

Catalysed by DPEP1, DPEP2, GLYATL2extracellular space

N-decanoylglycineReach from here →

membrane dipeptidase (LTD4)
decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

Catalysed by DPEP1, DPEP2, GLYATL2extracellular space

N-octanoylglycineReach from here →

membrane dipeptidase (LTD4)
octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

Catalysed by DPEP1, DPEP2, GLYATL2extracellular space

N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →

membrane dipeptidase (LTD4)
5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

Catalysed by DPEP1, DPEP2, GARTextracellular space

L-cystine-bis-glycineReach from here →

membrane dipeptidase (LTD4)
L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

Catalysed by DPEP1, DPEP2extracellular space

glycyldehydrophenylalanineReach from here →

membrane dipeptidase (LTD4)
glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

Catalysed by DPEP1, DPEP2extracellular space

an N-(fatty acyl)-glycineReach from here →

membrane dipeptidase (LTD4)
a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

Catalysed by DPEP1, DPEP2, GLYATL2extracellular space

N-(9Z,12Z-octadecadienoyl)-glycineReach from here →

membrane dipeptidase (LTD4)
(9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

Catalysed by DPEP1, DPEP2, GLYATL2extracellular space

acetylcholineReach from here →

transport of LTD4 (cytosol to extracellular)
transport of acetylcholine (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1B3extracellular space, cytosolOne of 4 routes

CHEBI:15570Reach from here →

membrane dipeptidase (LTD4)
transport of D-alanine and glycine (cytosol to extracellular)

Catalysed by DPEP1, DPEP2, SLC3A2, SLC7A10extracellular space, cytosolOne of 2 routes

L-leucineReach from here →

membrane dipeptidase (LTD4)
transport of glycine and leucine (cytosol to extracellular)

Catalysed by DPEP1, DPEP2, SLC7A5extracellular space, cytosolOne of 5 routes

CHEBI:15611Reach from here →

membrane dipeptidase (LTD4)
S-Adenosyl-L-methionine:glycine N-methyltransferase

Catalysed by DPEP1, DPEP2, GNMTextracellular space, cytosol

CHEBI:15699Reach from here →

membrane dipeptidase (LTD4)
transport of glycine and homoserine (cytosol to extracellular)

Catalysed by DPEP1, DPEP2, SLC7A5extracellular space, cytosolOne of 4 routes

bromideReach from here →

transport of GSH and LTD4 (cytosol to extracellular)
2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase

Catalysed by SLCO2A1, MGST3, GSTA4, GSTA1 and 14 moreextracellular space, cytosolOne of 2 routes

CHEBI:15971Reach from here →

membrane dipeptidase (LTD4)
transport of glycine and histidine (cytosol to extracellular)

Catalysed by DPEP1, DPEP2, SLC7A6extracellular space, cytosolOne of 2 routes

lithocholic acidReach from here →

transport of LTD4 (cytosol to extracellular)
transport of lithocholate (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

L-citrullineReach from here →

membrane dipeptidase (LTD4)
transport of citrulline and glycine (cytosol to extracellular)

Catalysed by DPEP1, DPEP2, SLC7A9, SLC3A1 and 1 moreextracellular space, cytosol

L-valineReach from here →

membrane dipeptidase (LTD4)
transport of glycine and valine (cytosol to extracellular)

Catalysed by DPEP1, DPEP2, SLC7A5extracellular space, cytosolOne of 4 routes

L-arginineReach from here →

membrane dipeptidase (LTD4)
transport of arginine and glycine (cytosol to extracellular)

Catalysed by DPEP1, DPEP2, SLC7A6extracellular space, cytosolOne of 2 routes

CHEBI:16523Reach from here →

membrane dipeptidase (LTD4)
transport of D-serine and glycine (cytosol to extracellular)

Catalysed by DPEP1, DPEP2, SLC3A2, SLC7A10extracellular space, cytosolOne of 2 routes

protein polypeptide chainReach from here →

membrane dipeptidase (LTD4)
PROTEIN_BS

Catalysed by DPEP1, DPEP2extracellular space, cytosol

CHEBI:16857Reach from here →

membrane dipeptidase (LTD4)
transport of glycine and threonine (cytosol to extracellular)

Catalysed by DPEP1, DPEP2, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 4 routes

glyoxylic acidReach from here →

membrane dipeptidase (LTD4)
glycine:oxygen oxidoreductase (deaminating)

Catalysed by DPEP1, DPEP2, DAOextracellular space, peroxisome

bilirubin IXalphaReach from here →

transport of LTD4 (cytosol to extracellular)
transport of bilirubin (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

taurolithocholateReach from here →

transport of LTD4 (cytosol to extracellular)
transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

L-isoleucineReach from here →

membrane dipeptidase (LTD4)
transport of glycine and isoleucine (cytosol to extracellular)

Catalysed by DPEP1, DPEP2, SLC7A5extracellular space, cytosolOne of 4 routes

CHEBI:17203Reach from here →

membrane dipeptidase (LTD4)
transport of glycine and proline (cytosol to extracellular)

Catalysed by DPEP1, DPEP2, SLC7A5, SLC7A6extracellular space, cytosolOne of 2 routes

CHEBI:17208Reach from here →

transport of GSH and LTD4 (cytosol to extracellular)
glutathione:dehydroascorbate oxidoreductase

Catalysed by SLCO2A1extracellular space, cytosol

homocysteineReach from here →

transport of GSH and LTD4 (cytosol to extracellular)
Formation of Homocystine

Catalysed by SLCO2A1extracellular space, cytosol

5-aminolevulinic acidReach from here →

membrane dipeptidase (LTD4)
succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

Catalysed by DPEP1, DPEP2, ALAS1, ALAS2 and 1 moreextracellular space, mitochondrial matrix

L-cysteineReach from here →

membrane dipeptidase (LTD4)
transport of cysteine and glycine (cytosol to extracellular)

Catalysed by DPEP1, DPEP2, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 5 routes

CHEBI:17895Reach from here →

membrane dipeptidase (LTD4)
transport of glycine and tyrosine (cytosol to extracellular)

Catalysed by DPEP1, DPEP2, SLC7A5extracellular space, cytosolOne of 4 routes