L-aspartate

Two steps

• CHEBI:15477Reach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by NAT8L, GLYAT, GLYATL2, GLYATL1mitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Production of Tiglylcarnitine

  Catalysed by NAT8L, CPT1A, CPT1Bmitochondrial matrix, cytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by NAT8L, HADHA, ACAA2, HADHBmitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by NAT8L, GLYATmitochondrial matrix

• isovaleryl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by NAT8L, GLYAT, GLYATL2, GLYATL1mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 11 routes

• CHEBI:15519Reach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. propanoyl-CoA C-acyltransferase

  Catalysed by NAT8L, ACAA1, SCP2, MYO5Bmitochondrial matrix, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Palmitate:CoA ligase (AMP-forming)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 11 routes

• oleoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by NAT8L, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Phenylacetate:CoA ligase

  Catalysed by NAT8Lmitochondrial matrix, cytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Propanoate:CoA ligase (AMP-forming)

  Catalysed by NAT8L, ACSS3, ACSS2, ACSS1mitochondrial matrix, cytosolOne of 43 routes

• CHEBI:15570Reach from here →
  1. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  2. transport of D-alanine and glutamine (cytosol to extracellular)

  Catalysed by SLC7A13, SLC3A2, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• (S)-malateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. transport of malate and OAA (cytosol to mitochondria)

  Catalysed by GOT2mitochondrial matrix, cytosolOne of 9 routes

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by SLC7A13, PAHinner side of the membrane, outer side of the membraneOne of 3 routes

• CHEBI:15650Reach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by NAT8L, ZDHHC11B, NAA10, ESCO2 and 29 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:15699Reach from here →
  1. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  2. transport of asparagine and homoserine (cytosol to extracellular)

  Catalysed by ASNS, SLC7A5cytosol, extracellular spaceOne of 29 routes

• CHEBI:15727Reach from here →
  1. L-aspartate 1-carboxy-lyase (beta-alanine-forming)
  2. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by GAD2, CARNS1cytosolOne of 2 routes

• CHEBI:15746Reach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by NAT8L, SAT1, SAT2mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:15765Reach from here →
  1. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  2. solute carrier (L-dopa)

  Catalysed by SLC7A13, SLC3A2, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• malonateReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)

  Catalysed by SLC25A14, SLC25A30, SLC25A10inner side of the membrane, outer side of the membraneOne of 2 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  2. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by SLC7A13, GFPT2, GFPT1inner side of the membrane, outer side of the membrane, cytosol

• N-acetyl-beta-D-glucosaminylamineReach from here →
  1. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)
  2. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by AGA

• thioredoxin dithiolReach from here →
  1. L-Aspartate:tRNA(Asp) ligase (AMP-forming)
  2. glycyl-tRNA(gly) phosphorylation

  Catalysed by DARS1cytosolOne of 2 routes

• CHEBI:15971Reach from here →
  1. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  2. transport of asparagine and histidine (cytosol to extracellular)

  Catalysed by ASNS, SLC7A6cytosol, extracellular spaceOne of 18 routes

• 11-cis-retinolReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by NAT8L, DGAT1, LRAT, AWAT1 and 2 moremitochondrial matrix, cytosol

• (R)-3-aminoisobutyric acidReach from here →
  1. oxaloacetate + L-alanine = L-aspartate + pyruvate
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by AGXT2mitochondrial matrix

• L-citrullineReach from here →
  1. L-Citrulline:L-aspartate ligase (AMP-forming)
  2. L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)

  Catalysed by ASS1cytosolOne of 18 routes

• L-arginineReach from here →
  1. L-Citrulline:L-aspartate ligase (AMP-forming)
  2. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by ASS1, ASLcytosolOne of 36 routes

• CHEBI:16523Reach from here →
  1. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  2. transport of D-serine and glutamine (cytosol to extracellular)

  Catalysed by SLC7A13, SLC3A2, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 2-phenylacetamideReach from here →
  1. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  2. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by SLC7A13, EPXinner side of the membrane, outer side of the membrane, cytosol

• CHEBI:16633Reach from here →
  1. oxaloacetate + L-alanine = L-aspartate + pyruvate
  2. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by AGXT2, SCLYcytosol

• Met-tRNA(Met)Reach from here →
  1. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  2. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SLC7A13, MARS1inner side of the membrane, outer side of the membrane, cytosol

• CHEBI:16668Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. 3-sulfino-L-alanine carboxy-lyase

  Catalysed by SLC25A12, SLC25A13, GAD1, CSADmitochondrial matrix, cytosol

• quinolinic acidReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. Transport of Quinolinic Acid

  Catalysed by SLC25A14, SLC25A30, SLC22A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  2. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC7A13, AADATinner side of the membrane, outer side of the membrane

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  2. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SLC7A13, CNDP2inner side of the membrane, outer side of the membrane

• tryptamineReach from here →
  1. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  2. L-tryptophan decarboxy-lyase

  Catalysed by SLC7A13, DDCinner side of the membrane, outer side of the membrane, cytosol

• 2-oxoglutaramateReach from here →
  1. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  2. L-Glutamine:pyruvate aminotransferase

  Catalysed by SLC7A13, KYAT1inner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• CHEBI:16857Reach from here →
  1. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  2. transport of asparagine and threonine (cytosol to extracellular)

  Catalysed by ASNS, SLC7A5cytosol, extracellular spaceOne of 34 routes

• oxalic acidReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. transport of oxalate and sulfate (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC26A6inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• L-isoleucineReach from here →
  1. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  2. transport of asparagine and isoleucine (cytosol to extracellular)

  Catalysed by ASNS, SLC7A5cytosol, extracellular spaceOne of 34 routes

• anilineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by NAT8L, NAT2, NAT1mitochondrial matrix, cytosol

• CHEBI:17312Reach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by NAT8Lmitochondrial matrix, cytosolOne of 2 routes

• sulfiteReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)

  Catalysed by SLC25A14, SLC25A30inner side of the membrane, outer side of the membraneOne of 2 routes

• D-aspartic acidReach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. transport of D-aspartate (cytosol to extracellular)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 1 moreextracellular space, cytosol

• CHEBI:17380Reach from here →
  1. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  2. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by SLC7A13, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. Aspartate Intake by System Asct-1 Transporter
  2. L-proline:(acceptor) oxidoreductase

  Catalysed by PRODH2extracellular space, cytosolOne of 2 routes

• AH2Reach from here →
  1. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by SLC7A13, CDKAL1inner side of the membrane, outer side of the membraneOne of 4 routes

• L-cysteineReach from here →
  1. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  2. transport of asparagine and cysteine (cytosol to extracellular)

  Catalysed by ASNS, SLC7A5cytosol, extracellular spaceOne of 50 routes

• indole-3-pyruvateReach from here →
  1. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  2. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by SLC7A13, IL4I1inner side of the membrane, outer side of the membraneOne of 2 routes