L-citrulline

Two steps

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. transport of citrulline and phenylalanine (cytosol to extracellular)
  2. L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase(4-hydroxylating)

  Catalysed by SLC7A6, PAHextracellular space, cytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. transport of alanine and citrulline (cytosol to extracellular)
  2. alanine racemase

  Catalysed by SLC7A6extracellular space, cytosolOne of 5 routes

• CHEBI:15611Reach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by SLC7A9, SLC3A1, SLC7A6, GNMTextracellular space, cytosol

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. transport of citrulline and phenylalanine (cytosol to extracellular)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by SLC7A6, PAHextracellular space, cytosolOne of 2 routes

• trimethylenediamineReach from here →
  1. transport of citrulline and lysine (cytosol to extracellular)
  2. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by SLC7A5, SLC7A6, DHPSextracellular space, cytosol

• CHEBI:15727Reach from here →
  1. transport of citrulline and histidine (cytosol to extracellular)
  2. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by SLC7A5, SLC7A6, CARNS1extracellular space, cytosol

• CHEBI:15765Reach from here →
  1. transport of citrulline and tyrosine (cytosol to extracellular)
  2. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by SLC7A6, THextracellular space, cytosolOne of 5 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. Carbamoyl-phosphate:L-ornithine carbamoyltransferase
  2. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by OTC, CADmitochondrial matrix, cytosol

• alpha-D-glucosamine 6-phosphateReach from here →
  1. transport of citrulline and glutamine (cytosol to extracellular)
  2. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by SLC7A6, GFPT2, GFPT1extracellular space, cytosol

• ureaReach from here →
  1. transport of arginine and citrulline (cytosol to extracellular)
  2. L-Arginine amidinohydrolase

  Catalysed by SLC7A5, SLC7A6, ARG1extracellular space, cytosolOne of 3 routes

• L-cystineReach from here →
  1. transport of arginine and citrulline (cytosol to extracellular)
  2. L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)

  Catalysed by SLC7A5, SLC7A6, SLC7A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 7 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. transport of alanine and citrulline (cytosol to extracellular)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC7A6, AGXT2extracellular space, cytosol, mitochondrial matrix

• iodideReach from here →
  1. transport of citrulline and tyrosine (cytosol to extracellular)
  2. thyroid peroxidase (iodine)

  Catalysed by SLC7A6, TPOextracellular space, cytosolOne of 2 routes

• nitric oxideReach from here →
  1. transport of arginine and citrulline (cytosol to extracellular)
  2. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by SLC7A5, SLC7A6, NOS3, NOS1 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. transport of citrulline and glutamine (cytosol to extracellular)
  2. transport of D-serine and glutamine (cytosol to extracellular)

  Catalysed by SLC7A6, SLC3A2, SLC7A10extracellular space, cytosolOne of 4 routes

• protein polypeptide chainReach from here →
  1. transport of citrulline and lysine (cytosol to extracellular)
  2. PROTEIN_BS

  Catalysed by SLC7A5, SLC7A6extracellular space, cytosolOne of 17 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15
  2. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by SLC7A9, ACY1extracellular space, cytosol

• 2-phenylacetamideReach from here →
  1. transport of citrulline and phenylalanine (cytosol to extracellular)
  2. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by SLC7A6, EPXextracellular space, cytosol

• CHEBI:16633Reach from here →
  1. transport of alanine and citrulline (cytosol to extracellular)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC7A6, SCLYextracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. transport of citrulline and methionine (cytosol to extracellular)
  2. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SLC7A6, MARS1extracellular space, cytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. transport of citrulline and methionine (cytosol to extracellular)
  2. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC7A6, AADATextracellular space, cytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. transport of citrulline and phenylalanine (cytosol to extracellular)
  2. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SLC7A6, CNDP2extracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. transport of citrulline and threonine (cytosol to extracellular)
  2. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by SLC7A6, SDS, SDSLextracellular space, cytosol

• tryptamineReach from here →
  1. transport of citrulline and tryptophan (cytosol to extracellular)
  2. L-tryptophan decarboxy-lyase

  Catalysed by SLC7A9, SLC3A1, SLC7A6, DDCextracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. transport of citrulline and glutamine (cytosol to extracellular)
  2. L-Glutamine:pyruvate aminotransferase

  Catalysed by SLC7A6, KYAT1extracellular space, cytosolOne of 3 routes

• CHEBI:16856Reach from here →
  1. transport of citrulline and cysteine (cytosol to extracellular)
  2. cystine to cysteine conversion

  Catalysed by SLC7A6extracellular space, cytosolOne of 2 routes

• glyoxylic acidReach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC7A9, SLC3A1, SLC7A6, DAOextracellular space, cytosol, peroxisome

• L-glutamic 5-semialdehydeReach from here →
  1. Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15
  2. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by SLC7A9, OATextracellular space, cytosol, mitochondrial matrix

• CHEBI:17380Reach from here →
  1. transport of citrulline and tryptophan (cytosol to extracellular)
  2. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by SLC7A9, SLC3A1, SLC7A6, SLC7A5extracellular space, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. transport of citrulline and proline (cytosol to extracellular)
  2. L-proline:(acceptor) oxidoreductase

  Catalysed by SLC7A6, PRODH2extracellular space, cytosolOne of 2 routes

• agmatineReach from here →
  1. transport of arginine and citrulline (cytosol to extracellular)
  2. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by SLC7A5, SLC7A6extracellular space, cytosol, mitochondrial matrix

• AH2Reach from here →
  1. transport of alanine and citrulline (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC7A6, MOCOSextracellular space, cytosolOne of 4 routes

• 5-aminolevulinic acidReach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by SLC7A9, SLC3A1, SLC7A6, ALAS1 and 2 moreextracellular space, cytosol, mitochondrial matrix

• indole-3-pyruvateReach from here →
  1. transport of citrulline and tryptophan (cytosol to extracellular)
  2. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by SLC7A9, SLC3A1, SLC7A6, IL4I1extracellular space, cytosolOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. transport of alanine and citrulline (cytosol to extracellular)
  2. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC7A6, AARS1extracellular space, cytosol

• trans-urocanateReach from here →
  1. transport of citrulline and histidine (cytosol to extracellular)
  2. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by SLC7A5, SLC7A6, HALextracellular space, cytosol

• 5-hydroxy-L-tryptophanReach from here →
  1. transport of citrulline and tryptophan (cytosol to extracellular)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC7A9, SLC3A1, SLC7A6, TPH1 and 1 moreextracellular space, cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. transport of citrulline and leucine (cytosol to extracellular)
  2. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by BCAT2extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• CHEBI:17927Reach from here →
  1. transport of arginine and citrulline (cytosol to extracellular)
  2. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by SLC7A5, SLC7A6, SLC3A2extracellular space, cytosol

• 3-phenylpyruvateReach from here →
  1. transport of citrulline and phenylalanine (cytosol to extracellular)
  2. Phenylalanine Transaminase, Mitochondrial

  Catalysed by SLC7A6, GOT2, TATextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• fumaric acidReach from here →
  1. L-Citrulline:L-aspartate ligase (AMP-forming)
  2. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by ASS1, ASLcytosolOne of 2 routes

• CHEBI:18095Reach from here →
  1. transport of alanine and citrulline (cytosol to extracellular)
  2. Transport of Hydroxy-Proline

  Catalysed by SLC7A6, SLC1A4extracellular space, cytosolOne of 4 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by SLC7A9, SLC3A1, SLC7A6, GARTextracellular space, cytosol

• 2-phenylethylamineReach from here →
  1. transport of citrulline and phenylalanine (cytosol to extracellular)
  2. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by SLC7A6, DDCextracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. transport of citrulline and glutamine (cytosol to extracellular)
  2. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by SLC7A6, PFASextracellular space, cytosol

• ophthalmateReach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by SLC7A9, SLC3A1, SLC7A6, GSSextracellular space, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. transport of citrulline and methionine (cytosol to extracellular)
  2. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by SLC7A6, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. transport of alanine and citrulline (cytosol to extracellular)
  2. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SLC7A6, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. transport of alanine and citrulline (cytosol to extracellular)
  2. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC7A6, AGXT2extracellular space, cytosolOne of 2 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SLC7A9, SLC3A1, SLC7A6, SHMT1extracellular space, cytosolOne of 2 routes