Se-methylselenocysteine

Three steps

• sarcosineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by SHMT1, PIPOXnucleus, cytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by SHMT1, SHMT2nucleus, cytosolOne of 3 routes

• (6R)-5,10-methenyltetrahydrofolateReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase

  Catalysed by SHMT1, MTHFD2, MTHFD2Lnucleus, cytosol, mitochondrial matrixOne of 8 routes

• N-acetyl-D-glucosamine 6-phosphateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate

  Catalysed by SCLY, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space

• an N-acylglycineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by SHMT1, GLYATL3, GLYAT, GLYATL2nucleus, cytosol

• guanidinoacetateReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. L-Arginine:glycine amidinotransferase

  Catalysed by SHMT1, GATMnucleus, cytosolOne of 2 routes

• D-threonineReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by SCLY, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• CMP-N-acetyl-beta-neuraminateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. CTP:N-acetylneuraminate cytidylyltransferase

  Catalysed by SCLY, NPL, CMAScytosol, nucleusOne of 2 routes

• L-tryptophanReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and tryptophan (cytosol to extracellular)

  Catalysed by SHMT1, SLC7A5nucleus, cytosol, extracellular spaceOne of 13 routes

• glutathioneReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by SHMT1, GSSnucleus, cytosol

• L-threonineReach from here →
  1. Methionine Synthase
  2. Selenomethionine methanethiol-lyase (deaminating)
  3. L-threonine = 2-oxobutanoate + NH4(+)

  Catalysed by CTH, SDS, SDSLnucleus, cytosolOne of 5 routes

• L-kynurenineReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by SCLY, KYNUcytosol

• beta-alanineReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

  Catalysed by SCLY, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• leukotriene C4Reach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. leukotriene C4 hydrolysis

  Catalysed by SHMT1nucleus, cytosol

• 2-hydroxy-3-oxopropanoateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. L-Serine:pyruvate aminotransferase
  3. hydroxypyruvate aldose-ketose-isomerase

  Catalysed by SCLY, AGXT, HYIcytosolOne of 2 routes

• L-asparagineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of asparagine and glycine (cytosol to extracellular)

  Catalysed by SHMT1nucleus, cytosol, extracellular spaceOne of 13 routes

• L-phenylalanineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. transport of glycine and phenylalanine (cytosol to extracellular)

  Catalysed by SHMT1, SLC7A5nucleus, cytosol, extracellular spaceOne of 19 routes

• 3-hydroxy-L-kynurenineReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by SCLY, KYNUcytosol

• L-homocysteineReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by SCLY, TYW1B, TYW1, BHMT2cytosol

• S-methyl-L-methionineReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by SCLY, TYW1B, TYW1, BHMT2cytosol

• N-acetylputrescineReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by SCLY, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space

• (2R)-2-phosphoglycerateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. pyruvate kinase (dTDP)
  3. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)

  Catalysed by SCLY, PKM, PKLR, ENO1 and 2 morecytosol

• L-tyrosineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by SHMT1, AADATnucleus, cytosol

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SHMT1, AGXT2nucleus, cytosolOne of 8 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by SCLY, SLC1A4cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. Methionine Synthase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by ATIC, ADSLnucleus, cytosolOne of 2 routes

• kynurenateReach from here →
  1. Methionine Synthase
  2. Selenomethionine methanethiol-lyase (deaminating)
  3. 2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O

  Catalysed by CTH, AADATnucleus, cytosolOne of 2 routes

• 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamideReach from here →
  1. Methionine Synthase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate

  Catalysed by ATICnucleus, cytosolOne of 2 routes

• N(8)-acetylspermidineReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(8)-acetylspermidine + H2O = spermidine + acetate

  Catalysed by SCLY, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space

• (S)-3-amino-2-methylpropanoateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-3-amino-isobutanoate:2-oxoglutarate aminotransferase

  Catalysed by SCLY, AGXT2, ABATcytosol, mitochondrial matrix

• phosphoenolpyruvateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. Pyruvate:carbon-dioxide ligase (ADP-forming)
  3. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2

  Catalysed by SCLY, PC, PCK1, PCK2cytosol, mitochondrial matrix

• an N-acetyl-L-cysteine-S-conjugateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

  Catalysed by SCLY, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space

• L-methionine (S)-S-oxideReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by SCLY, TYW1B, TYW1, MSRAcytosol

• L-methionine (R)-S-oxideReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by SCLY, TYW1B, TYW1, MSRB3 and 2 morecytosol

• N-formimidoyl-L-glutamateReach from here →
  1. Methionine Synthase
  2. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
  3. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase

  Catalysed by FTCDnucleus, cytosol

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by SHMT1, GLYATL2nucleus, cytosolOne of 2 routes

• (2S)-2-phospholactateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate

  Catalysed by SCLY, LDHA, LDHB, LDHC and 3 morecytosolOne of 2 routes

• L-prolineReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by SCLY, SLC1A4cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin E2Reach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

  Catalysed by SCLY, LDHA, LDHB, LDHC and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-benzoylglycineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by SHMT1nucleus, cytosol, mitochondrial matrixOne of 2 routes

• L-cysteinylglycineReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SCLY, GGTLC3, GGT1, GGT5 and 3 morecytosolOne of 2 routes

• dTMPReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase

  Catalysed by SHMT1, TYMSnucleus, cytosolOne of 6 routes

• Mo-molybdopterinReach from here →
  1. S-Adenosyl-L-methionine:thiol S-methyltransferase
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SCLY, MOCOScytosol

• 3',3'-cGAMPReach from here →
  1. Methionine Synthase
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
  3. 3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)

  Catalysed by ATIC, SLC19A1nucleus, cytosol, inner side of the membrane, outer side of the membrane

• (2S)-2-aminobutanoateReach from here →
  1. Methionine Synthase
  2. Selenomethionine methanethiol-lyase (deaminating)
  3. 2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O

  Catalysed by CTH, AADATnucleus, cytosolOne of 7 routes

• 2-iminobutanoateReach from here →
  1. Methionine Synthase
  2. Selenomethionine methanethiol-lyase (deaminating)
  3. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)

  Catalysed by CTH, RIDAnucleus, cytosol

• 2-aminoprop-2-enoateReach from here →
  1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
  2. D-serine = pyruvate + NH4(+)
  3. D-serine = 2-aminoprop-2-enoate + H2O

  Catalysed by SCLY, SRRcytosol

• glycodeoxycholateReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. Glycodeoxycholate amidohydrolase

  Catalysed by SHMT1nucleus, cytosolOne of 2 routes

• N-tetradecanoylglycineReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by SHMT1, GLYATL2nucleus, cytosol

• N-eicosanoylglycinateReach from here →
  1. Methionine Synthase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by SHMT1, BAATnucleus, cytosol