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N-formimidoyl-L-glutamate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

11 compounds within 3 steps: 1 in 1, 2 in 2, 8 in 3

Does it reach a compound?

One step

5-formimidoyltetrahydrofolateReach from here →
1. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
Catalysed by FTCDcytosolOne of 2 routes

Two steps

5,6,7,8-tetrahydrofolic acidReach from here →
1. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
2. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
Catalysed by FTCDcytosol
(6R)-5,10-methenyltetrahydrofolateReach from here →
1. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
2. 5-Formiminotetrahydrofolate ammonia-lyase (cyclizing)
Catalysed by FTCDcytosolOne of 2 routes

Three steps

(6R)-5,10-methylene-5,6,7,8-tetrahydrofolateReach from here →
Catalysed by FTCD, MTHFD2, MTHFD2Lcytosol
10-formyltetrahydrofolic acidReach from here →

Catalysed by FTCD, MTHFD1

cytosol

One of 5 routes

5-methyltetrahydrofolic acidReach from here →

5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
histamine N-methyltransferase (SAM)

Catalysed by FTCD, HNMTcytosol

(6R)-10-formyltetrahydrofolateReach from here →

5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
5-Formiminotetrahydrofolate ammonia-lyase (cyclizing)
(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)

Catalysed by FTCD, MTHFD1, MTHFD2, MTHFD2Lcytosol

(6R)-5,10-methylenetetrahydrofolic acidReach from here →

5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
5-Formiminotetrahydrofolate ammonia-lyase (cyclizing)
5,10-methylenetetrahydrofolate:NAD+ oxidoreductase

Catalysed by FTCD, MTHFD2, MTHFD2Lcytosol, mitochondrial matrixOne of 9 routes

glycineReach from here →

5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

Catalysed by FTCD, SHMT1cytosolOne of 3 routes

7,8-dihydrofolateReach from here →

5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase

Catalysed by FTCD, DHFR, DHFR2cytosolOne of 3 routes

5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideReach from here →

5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

Catalysed by FTCD, ATICcytosol