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Proteins/UNIPROT:P31939
Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization..
Function from UniProtKB (P31939), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
134 statements
134 statements · 7 reference databases · Subject: ATIC · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
6 reactions
Catalysed by ATIC
Reaction pageReversibleBalancedEC 3.5.4.10cytosol
Human-GEM MAR04038CC BY 4.0Reference data
10-formyltetrahydrofolic acid+5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideCHEBI:18381+5,6,7,8-tetrahydrofolic acid
Catalysed by ATIC
Reaction pageReversibleBalancedEC 2.1.2.3cytosol
9 names
Resolves to: ATIC
IMP+water5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
Catalysed by ATIC
Reaction pageRight to leftBalanced
Rhea RHEA:18445CC BY 4.0Reference data
(6R)-10-formyltetrahydrofolate+5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide+(6S)-5,6,7,8-tetrahydrofolate
Catalysed by ATIC
Reaction pageLeft to rightBalanced
Rhea RHEA:22192CC BY 4.0Reference data
10-formyldihydrofolate+5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide+7,8-dihydrofolate
Catalysed by ATIC
Reaction pageLeft to rightBalanced
Rhea RHEA:59144CC BY 4.0Reference data
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide+10-formyldihydrofolate6-thio-IMP+7,8-dihydrofolate+water
Catalysed by ATIC
Reaction pageLeft to rightBalanced
Rhea RHEA:62676CC BY 4.0Reference data