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Proteins/UNIPROT:P41440
Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions. Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses. Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also mediates the import of antifolate drug methotrexate. 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity..
Function from UniProtKB (P41440), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
1 row
56 statements
56 statements · 7 reference databases · Subject: SLC19A1 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
18 reactions
MAM01100e+waterMAM01100c+water
Transported by SLC19A1
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR00050CC BY 4.0Reference data
5-methyltetrahydrofolic acid+water5-methyltetrahydrofolic acid+water
Transported by SLC19A1
Reaction pageReversibleBalancedextracellular space, cytosol
15 names
Resolves to: SLC19A1
folic acid+waterfolic acid+water
Transported by SLC19A1
Reaction pageReversibleBalancedEC 3.1.3.11extracellular space, cytosol
Human-GEM MAR01047CC BY 4.0Reference data
water+5,6,7,8-tetrahydrofolic acidwater+5,6,7,8-tetrahydrofolic acid
Transported by SLC19A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR01780CC BY 4.0Reference data
water+MAM02983ewater+MAM02983c
Transported by SLC19A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR01782CC BY 4.0Reference data
3water+thiamine triphosphate3water+thiamine triphosphate
Transported by SLC19A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR01793CC BY 4.0Reference data
Transported by SLC19A1
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR04942CC BY 4.0Reference data
Transported by SLC19A1
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR04944CC BY 4.0Reference data
MAM01100c+waterMAM01100e+water
Transported by SLC19A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR07682CC BY 4.0Reference data
5-methyltetrahydrofolic acid+water5-methyltetrahydrofolic acid+water
Transported by SLC19A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR07683CC BY 4.0Reference data
folic acid+waterfolic acid+water
Transported by SLC19A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR07684CC BY 4.0Reference data
water+5,6,7,8-tetrahydrofolic acidwater+5,6,7,8-tetrahydrofolic acid
Transported by SLC19A1
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR07685CC BY 4.0Reference data