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Proteins/UNIPROT:Q9UJ68
[Isoform 1]: Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Plays a crucial role in repairing oxidized methionine residues in key lens proteins, such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c (CYCS), thereby restoring their function and maintaining lens transparency (By similarity)..
Function from UniProtKB (Q9UJ68), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
410 statements
410 statements · 6 reference databases · Subject: MSRA · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
3 reactions
water+thioredoxin disulfide+MAM02704cMAM02703c+thioredoxin dithiol
Catalysed by MSRA
Reaction pageReversibleBalance undeterminableEC 1.8.4.11cytosol
Human-GEM MAR09544CC BY 4.0Reference data
L-methionyl-[protein]+[thioredoxin]-disulfide+waterL-methionyl-(S)-S-oxide-[protein]+[thioredoxin]-dithiol
Catalysed by MSRA
Reaction pageDirection not assertedBalance undeterminable
4 names
Resolves to: MSRA
[thioredoxin]-disulfide+L-methionine+waterL-methionine (S)-S-oxide+[thioredoxin]-dithiol
Catalysed by MSRA
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:19993CC BY 4.0Reference data