2-oxo-3-sulfanylpropanoate

Three steps

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• kinetensinReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. Chymase

  Catalysed by GOT2, GOT1, SLC7A5, CMA1cytosol, extracellular spaceOne of 3 routes

• an N-(fatty acyl)-glycineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• (7Z)-octadecenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by GOT2, GOT1, NAGS, CPT1A and 2 morecytosol, mitochondrial matrixOne of 3 routes

• acetaldehydeReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and threonine (cytosol to extracellular)
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by GOT2, GOT1, SLC7A5cytosol, extracellular space

• CHEBI:15345Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by GOT2, GOT1, NAGS, AACScytosol, mitochondrial matrixOne of 5 routes

• acetoneReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. Acetoacetate carboxy-lyase (acetone-forming)

  Catalysed by MPST, TSTcytosol, mitochondrial matrix

• cholineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by GOT2, GOT1, NAGS, CHATcytosol, mitochondrial matrix, nucleusOne of 2 routes

• acetylcholineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. transport of acetylcholine and GSH (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)

  Catalysed by GOT2, GOT1, SLC7A5, TPH1 and 1 morecytosol, extracellular spaceOne of 3 routes

• CHEBI:15380Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by GOT2, GOT1, NAGS, ALAS1 and 1 morecytosol, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by GOT2, GOT1, NAGS, GLYAT and 2 morecytosol, mitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Production of Tiglylcarnitine

  Catalysed by GOT2, GOT1, NAGS, CPT1A and 1 morecytosol, mitochondrial matrixOne of 2 routes

• isobutyryl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by GOT2, GOT1, NAGS, HADHA and 2 morecytosol, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by GOT2, GOT1, NAGS, GLYATcytosol, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by GOT2, GOT1, NAGS, GLYAT and 2 morecytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 11 routes

• CHEBI:15519Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. propanoyl-CoA C-acyltransferase

  Catalysed by GOT2, GOT1, NAGS, ACAA1 and 2 morecytosol, mitochondrial matrix, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 11 routes

• oleoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by GOT2, GOT1, NAGS, CPT1A and 2 morecytosol, mitochondrial matrixOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Phenylacetate:CoA ligase

  Catalysed by GOT2, GOT1, NAGScytosol, mitochondrial matrixOne of 3 routes

• propionyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by GOT2, GOT1, NAGS, ACSS3 and 2 morecytosol, mitochondrial matrixOne of 48 routes

• CHEBI:15570Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular spaceOne of 5 routes

• CHEBI:15611Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• 15(S)-HPETEReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by MPST, TST, TSTD1, GPX5 and 8 morecytosol

• 10-formyltetrahydrofolic acidReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by GOT2, GOT1, SLC7A5, TPH1 and 1 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:15650Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by GOT2, GOT1, NAGS, ZDHHC11B and 31 morecytosol, mitochondrial matrixOne of 4 routes

• betaine aldehydeReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. choline + A = betaine aldehyde + AH2

  Catalysed by GOT2, GOT1, MOCOS, CHDHcytosol

• trimethylenediamineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and lysine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by GOT2, GOT1, SLC7A6, DHPScytosol, extracellular space

• CHEBI:15727Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by GOT2, GOT1, NAGS, NAA10cytosol, mitochondrial matrixOne of 2 routes

• CHEBI:15746Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by GOT2, GOT1, NAGS, SAT1 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:15765Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by GOT2, GOT1, SLC7A5, THcytosol, extracellular spaceOne of 5 routes

• malonateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)

  Catalysed by MPST, TST, SLC25A14, SLC25A30 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• bromideReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. 2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase

  Catalysed by GOT2, GOT1, MGST3, GSTA4 and 15 morecytosolOne of 2 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 3 morecytosol, extracellular space

• thioredoxin dithiolReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. L-Cysteine:tRNA(Cys) ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by GOT2, GOT1, CARS1cytosolOne of 2 routes

• a halide anionReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by MPST, TSTD1, GSTT4, GSTA4 and 21 more

• CHEBI:16174Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. pyruvate kinase (dTDP)
  3. nucleoside-diphosphate kinase (dADP)

  Catalysed by MPST, TST, PKM, PKLR and 6 morecytosolOne of 3 routes

• ureaReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by GOT2, GOT1, SLC7A6, ARG1cytosol, extracellular spaceOne of 3 routes

• CHEBI:16284Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. pyruvate kinase (dTDP)
  3. deoxythymidylate kinase (dADP)

  Catalysed by MPST, TST, PKM, PKLR and 1 morecytosol, mitochondrial matrixOne of 3 routes

• 11-cis-retinolReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by GOT2, GOT1, NAGS, DGAT1 and 4 morecytosol, mitochondrial matrix

• (R)-3-aminoisobutyric acidReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of alanine and cysteine (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by GOT2, GOT1, SLC7A5, AGXT2cytosol, extracellular space, mitochondrial matrixOne of 3 routes

• lithocholic acidReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. transport of GSH and lithocholate (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• (R)-carnitineReach from here →
  1. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)

  Catalysed by AADAT, SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• iodideReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by GOT2, GOT1, SLC7A5, TPOcytosol, extracellular spaceOne of 3 routes

• ubiquinonesReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of fumarate and thiosulfate (cytosol to mitochondria)
  3. succinate:quinone oxidoreductase

  Catalysed by MPST, TST, SLC25A10, SDHD and 3 morecytosol, mitochondrial matrix

• nitric oxideReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by GOT2, GOT1, SLC7A6, NOS3 and 2 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:16497Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. pyruvate kinase (dTDP)
  3. dGTP:pyruvate 2-O-phosphotransferase

  Catalysed by MPST, TST, PKM, PKLRcytosol