thiosulfate

Three steps

• all-trans-retinoic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. transport of pyruvate and retinoate (cytosol to extracellular)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• D-threo-isocitrateReach from here →
  1. transport of malate and thiosulfate (cytosol to mitochondria)
  2. Citrate Transport, Mitochondrial
  3. citrate = D-threo-isocitrate

  Catalysed by SLC25A10, SLC25A1, ACO1, ACO2mitochondrial matrix, cytosolOne of 3 routes

• L-leucineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of cysteine and leucine (cytosol to extracellular)

  Catalysed by CBS, SLC7A9, SLC3A1cytosol, extracellular spaceOne of 8 routes

• CHEBI:15650Reach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and leukotriene E4 (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:15699Reach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of cysteine and homoserine (cytosol to extracellular)

  Catalysed by CBS, SLC7A5cytosol, extracellular spaceOne of 3 routes

• trans-aconitateReach from here →
  1. transport of malate and thiosulfate (cytosol to mitochondria)
  2. Citrate Transport, Mitochondrial
  3. trans-aconitate(in) + citrate(out) = trans-aconitate(out) + citrate(in)

  Catalysed by SLC25A10, SLC25A1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• formateReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)
  3. oxalate(in) + formate(out) = oxalate(out) + formate(in)

  Catalysed by SLC25A14, SLC26A2, SLC25A30, SLC26A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• nicotinic acid D-ribonucleotideReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. Transport of Quinolinic Acid
  3. Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating)

  Catalysed by SLC22A6, QPRTcytosol, extracellular space

• bromideReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. 2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 23 morecytosolOne of 2 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by SLC25A14, SLC25A30, CADcytosol, inner side of the membrane, outer side of the membrane

• beta-nicotinamide D-ribosideReach from here →
  1. transport of fumarate and thiosulfate (cytosol to mitochondria)
  2. a quinone + succinate = fumarate + a quinol
  3. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol

  Catalysed by SLC25A10, SDHB, NQO2mitochondrial matrix, cytosol

• CHEBI:15971Reach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of cysteine and histidine (cytosol to extracellular)

  Catalysed by CBS, SLC7A6cytosol, extracellular spaceOne of 3 routes

• ferricytochrome cReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion

  Catalysed by MPST, TST, SUOXmitochondrial matrix, cytosolOne of 4 routes

• androsteroneReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. steroid sulfatase (androsterone sulfate)
  3. steroid sulfatase (androsterone sulfate)

  Catalysed by STScytosolOne of 3 routes

• a halide anionReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by TSTD1, GSTT4, GSTA4, GSTZ1 and 20 morecytosol

• 2-methyl-3-oxopropanoic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by MPST, TST, AGXT2mitochondrial matrix, cytosol

• lithocholic acidReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and lithocholate (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• 17beta-hydroxy-5alpha-androstan-3-oneReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. steroid sulfatase (5-alpha-dihydrotestosterone)
  3. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by STScytosolOne of 3 routes

• L-citrullineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of citrulline and cysteine (cytosol to extracellular)

  Catalysed by CBS, SLC7A6cytosol, extracellular spaceOne of 3 routes

• iodideReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by SLC26A6, SLC26A4cytosol, extracellular space

• cis-aconitateReach from here →
  1. transport of malate and thiosulfate (cytosol to mitochondria)
  2. Citrate Transport, Mitochondrial
  3. cis-aconitate(in) + citrate(out) = cis-aconitate(out) + citrate(in)

  Catalysed by SLC25A10, SLC25A1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-valineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of cysteine and valine (cytosol to extracellular)

  Catalysed by CBS, SLC7A5cytosol, extracellular spaceOne of 7 routes

• L-arginineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of arginine and cysteine (cytosol to extracellular)

  Catalysed by CBS, SLC7A6cytosol, extracellular spaceOne of 10 routes

• protein polypeptide chainReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. PROTEIN_BS

  Catalysed by CBScytosolOne of 2 routes

• pregnenoloneReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. Steryl-Sulfatase
  3. Pregnenolone-sulfate sulfohydrolase

  Catalysed by STScytosol, Golgi apparatusOne of 4 routes

• (S)-lactateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by MPST, TST, LDHA, LDHB and 3 moremitochondrial matrix, cytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. transport of malate and thiosulfate (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC25A10, CLYBL, AADATmitochondrial matrix, cytosol

• 2-oxobutanoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by MPST, TST, AGXT2mitochondrial matrix, cytosolOne of 2 routes

• 2-oxoglutaramateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by MPST, TST, KYAT1mitochondrial matrix, cytosolOne of 2 routes

• formaldehydeReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
  3. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

  Catalysed by SELENBP1cytosol

• CHEBI:16857Reach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of cysteine and threonine (cytosol to extracellular)

  Catalysed by CBS, SLC7A5cytosol, extracellular spaceOne of 5 routes

• N-acetyl-L-aspartateReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by SLC25A14, SLC25A30, NAT8Lcytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• bilirubin IXalphaReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of bilirubin and GSH (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• 4-maleylacetoacetateReach from here →
  1. transport of fumarate and thiosulfate (cytosol to mitochondria)
  2. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)
  3. 4-maleylacetoacetate = 4-fumarylacetoacetate

  Catalysed by SLC25A10, FAH, GSTZ1mitochondrial matrix, cytosol

• taurolithocholateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and taurolithocholate (cytosol to extracellular)

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by MPST, TST, AGXTmitochondrial matrix, cytosol

• L-isoleucineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of cysteine and isoleucine (cytosol to extracellular)

  Catalysed by CBS, SLC7A5cytosol, extracellular spaceOne of 6 routes

• CHEBI:17203Reach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of cysteine and proline (cytosol to extracellular)

  Catalysed by CBS, SLC7A5cytosol, extracellular spaceOne of 6 routes

• CHEBI:17208Reach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. glutathione:dehydroascorbate oxidoreductase

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 6 morecytosol

• homocysteineReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. Formation of Homocystine

  Catalysed by TSTD1, GPX5, GPX1, GPX2 and 6 morecytosol

• itaconateReach from here →
  1. transport of malate and thiosulfate (cytosol to mitochondria)
  2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  3. cis-aconitate carboxy-lyase

  Catalysed by SLC25A10, SLC25A1, ACOD1mitochondrial matrix, cytosol

• estroneReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. estrone 3-sulfate + H2O = estrone + sulfate + H(+)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by STScytosolOne of 3 routes

• propanoateReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by STS, SLC22A9cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• aceneuramateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by MPST, TST, NPLmitochondrial matrix, cytosol

• 5'-deoxyadenosineReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by MPST, TST, TYW1B, TYW1mitochondrial matrix, cytosol

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. transport of fumarate and thiosulfate (cytosol to mitochondria)
  2. a quinone + succinate = fumarate + a quinol
  3. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)

  Catalysed by SLC25A10, SDHB, PRODH, PRODH2mitochondrial matrix, cytosol

• indole-3-pyruvateReach from here →
  1. transport of malate and thiosulfate (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine

  Catalysed by SLC25A10, CLYBL, AADATmitochondrial matrix, cytosol

• 3,3'-diiodo-L-thyronineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. Steryl-Sulfatase
  3. Steryl-Sulfatase

  Catalysed by STScytosol, Golgi apparatusOne of 3 routes

• glycine betaineReach from here →
  1. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SLC26A6, SLC6A12cytosol, extracellular spaceOne of 3 routes