CHEBI:18095

Three steps

• 2-methyl-3-oxopropanoic acidReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (S)-3-amino-2-methylpropionate transaminase (2-methyl-3-oxopropanoate)

  Catalysed by SLC1A4, AGXT2, ABATextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• succinic semialdehydeReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. 4-aminobutanoate:2-oxoglutarate aminotransferase

  Catalysed by CLTRN, SLC6A20, SLC6A12, ABATextracellular space, cytosol, mitochondrial matrix

• 11-cis-retinolReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by SLC1A4, DGAT1, LRAT, AWAT1 and 2 moreextracellular space, cytosol, mitochondrial matrix

• cob(II)alaminReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2

  Catalysed by SLC1A4, MOCOS, MTRRextracellular space, cytosol

• (R)-carnitineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of betaine and chloride (cytosol to extracellular)
  3. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)

  Catalysed by CLTRN, SLC6A20, SLC6A12, SLC22A5extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• oxaloacetateReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Pyruvate:carbon-dioxide ligase (ADP-forming)

  Catalysed by SLC1A4, AGXT2, PCextracellular space, cytosol, mitochondrial matrixOne of 9 routes

• nitric oxideReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by CLTRN, SLC6A20, SLC6A14, NOS3 and 2 moreextracellular space, cytosolOne of 3 routes

• selaneReach from here →
  1. Transport of Hydroxy-Proline
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC1A4, SCLYextracellular space, cytosolOne of 3 routes

• CHEBI:16523Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 2 moreextracellular space, cytosolOne of 4 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. Transport of Hydroxy-Proline
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by SLC1A4, SLC7A6, ACY1extracellular space, cytosol

• 2-phenylacetamideReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by CLTRN, SLC6A20, SLC6A14, EPXextracellular space, cytosol

• anthranilateReach from here →
  1. Transport of Hydroxy-Proline
  2. L-kynurenine + H2O = anthranilate + L-alanine + H(+)
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by SLC1A4, KYNUextracellular space, cytosol

• D-alanyl-D-alanineReach from here →
  1. Transport of Hydroxy-Proline
  2. alanine racemase
  3. Formation of Alanylalanine

  Catalysed by SLC1A4extracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A14, MARS1extracellular space, cytosol

• (S)-lactateReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by SLC1A4, AGXT2, LDHA, LDHB and 3 moreextracellular space, cytosol, mitochondrial matrix

• quinolinic acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of Quinolinic Acid

  Catalysed by CLTRN, SLC6A20, SLC26A6, SLC22A6extracellular space, cytosolOne of 2 routes

• 3'-deoxy-3',4'-didehydro-CTPReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

  Catalysed by SLC1A4, MOCOS, RSAD2extracellular space, cytosol

• pyridoxineReach from here →
  1. Transport of Hydroxy-Proline
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. pyridoxine-5'-phosphate phosphohydrolase

  Catalysed by SLC1A4, SCLY, PHOSPHO2, PDXPextracellular space, cytosolOne of 2 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by CLTRN, SLC6A20, SLC6A14, AADATextracellular space, cytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by CLTRN, SLC6A20, SLC6A14, CNDP2extracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Threonine by Atb0 Transporter
  3. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A14, SDS and 1 moreextracellular space, cytosolOne of 6 routes

• tryptamineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan decarboxy-lyase

  Catalysed by CLTRN, SLC6A20, SLC6A14, DDCextracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by CLTRN, SLC6A20, SLC6A14, KYAT1extracellular space, cytosolOne of 5 routes

• (S)-2-hydroxyglutarateReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2

  Catalysed by SLC1A4, MOCOS, L2HGDHextracellular space, cytosol

• 3-fumarylpyruvateReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by SLC1A4, AGXT2, FAHD1extracellular space, cytosol, mitochondrial matrix

• CHEBI:16856Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosolOne of 3 routes

• glyoxylic acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosol, peroxisome

• trans-1,2-dithiane-4,5-diolReach from here →
  1. Transport of Hydroxy-Proline
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. selenocysteine lyase (dithiothreitol)

  Catalysed by SLC1A4, SCLYextracellular space, cytosol

• creatineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of Guanidinoacetic Acid
  3. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase

  Catalysed by CLTRN, SLC6A20, GAMTextracellular space, cytosolOne of 2 routes

• N-acetyl-L-aspartateReach from here →
  1. Transport of Hydroxy-Proline
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by SLC1A4, AGXT2, NAT8Lextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of (R)-3-hydroxybutanoate and formate (cytosol to extracellular)

  Catalysed by CLTRN, SLC6A20, SLC26A4, SLC16A4 and 3 moreextracellular space, cytosolOne of 4 routes

• taurolithocholateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. bile acid-CoA:amino acid N-acyltransferase (lithocholate)

  Catalysed by CLTRN, SLC6A20, SLC6A6, BAATextracellular space, cytosolOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by SLC1A4, AGXT2, AGXTextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• L-glutamic 5-semialdehydeReach from here →
  1. Transport of Hydroxy-Proline
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by SLC1A4, SLC7A6, OATextracellular space, cytosol, mitochondrial matrix

• anilineReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by SLC1A4, NAT2, NAT1extracellular space, cytosol, mitochondrial matrix

• aceneuramateReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by SLC1A4, AGXT2, NPLextracellular space, cytosol, mitochondrial matrix

• CHEBI:17312Reach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by SLC1A4extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by SLC1A4, AGXT2, TYW1B, TYW1extracellular space, cytosol, mitochondrial matrixOne of 5 routes

• linoleic acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by CLTRN, SLC6A20, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• sulfiteReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)

  Catalysed by CLTRN, SLC6A20, SLC26A6, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• D-aspartic acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of D-aspartate (cytosol to extracellular)

  Catalysed by CLTRN, SLC6A20, SLC12A2, SLC12A1 and 5 moreextracellular space, cytosol

• CHEBI:17380Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by CLTRN, SLC6A20, SLC6A14, SLC7A5extracellular space, cytosolOne of 3 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase
  2. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
  3. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)

  Catalysed by PYCR1, PYCR3, PYCR2, PRODH2 and 1 morecytosolOne of 4 routes

• agmatineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A14extracellular space, cytosol, mitochondrial matrix

• enol-oxaloacetateReach from here →
  1. trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase
  2. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
  3. (R)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by PYCR1, PYCR3, PYCR2, PRODH2 and 2 morecytosolOne of 2 routes

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by CLTRN, SLC6A20, SLC6A14, CPT2 and 1 moreextracellular space, cytosol, peroxisomeOne of 10 routes

• 5-aminolevulinic acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 3 moreextracellular space, cytosol, mitochondrial matrix

• diiodineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. iodide:hydrogen-peroxide oxidoreductase

  Catalysed by CLTRN, SLC6A20, SLC26A4, TPOextracellular space, cytosolOne of 2 routes

• indole-3-pyruvateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by CLTRN, SLC6A20, SLC6A14, IL4I1extracellular space, cytosolOne of 2 routes

• 3,3',5'-triiodo-L-thyronine sulfateReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2

  Catalysed by SLC1A4, MOCOS, DIO1extracellular space, cytosol