Loading the page.
Proteins/UNIPROT:P32322
Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H. At physiologic concentrations, has higher specific activity in the presence of NADH. Involved in the cellular response to oxidative stress..
Function from UniProtKB (P32322), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
398 statements
398 statements · 7 reference databases · Subject: PYCR1 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
8 reactions
(S)-1-pyrroline-5-carboxylate+2proton+NADH(2-)NAD(+)+CHEBI:17203
Reaction pageLeft to rightBalancedEC 1.5.1.2mitochondrial matrix
Human-GEM MAR03837CC BY 4.0Reference data
NAD(+)+CHEBI:180952proton+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+NADH(2-)
2 names
Resolves to: PYCR1
Reaction pageLeft to rightBalancedEC 1.5.1.2cytosol
Human-GEM MAR04778CC BY 4.0Reference data
NAD(+)+CHEBI:180952proton+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+NADH(2-)
Catalysed by PYCR3 or PYCR2 or PYCR1
Reaction pageLeft to rightBalancedEC 1.5.1.2mitochondrial matrix
Human-GEM MAR04779CC BY 4.0Reference data
NADP(3-)+CHEBI:180952proton+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+NADPH(4-)
Catalysed by PYCR3 or PYCR2 or PYCR1
Reaction pageLeft to rightBalancedEC 1.5.1.2cytosol
Human-GEM MAR04780CC BY 4.0Reference data
NADP(3-)+CHEBI:180952proton+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+NADPH(4-)
Catalysed by PYCR3 or PYCR2 or PYCR1
Reaction pageLeft to rightBalancedEC 1.5.1.2mitochondrial matrix
Human-GEM MAR04781CC BY 4.0Reference data
(S)-1-pyrroline-5-carboxylate+2proton+NADPH(4-)NADP(3-)+CHEBI:17203
Reaction pageLeft to rightBalancedEC 1.5.1.2mitochondrial matrix
Human-GEM MAR08609CC BY 4.0Reference data
L-proline+NAD(1-)(S)-1-pyrroline-5-carboxylate+NADH(2-)+2hydron
Catalysed by PYCR1 or PYCR3 or PYCR2
Reaction pageRight to leftBalanced
Rhea RHEA:14105CC BY 4.0Reference data
L-proline+NADP(3-)(S)-1-pyrroline-5-carboxylate+NADPH(4-)+2hydron
Catalysed by PYCR1 or PYCR3 or PYCR2
Reaction pageRight to leftBalanced
Rhea RHEA:14109CC BY 4.0Reference data