2'-deoxyuridine

Three steps

• hypoxanthineReach from here →
  1. 2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil
  2. 2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
  3. Deoxyinosine:orthophosphate ribosyltransferase

  Catalysed by UPP2, UPP1, PNPcytosolOne of 2 routes

• L-cysteineReach from here →
  1. thymidine kinase (deoxyuridine)
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• cytidineReach from here →
  1. deoxyuridine:orthophosphate 2-deoxy-D-ribosyltransferase
  2. uridine:phosphate alpha-D-ribosyltransferase
  3. cytidine + H2O + H(+) = uridine + NH4(+)

  Catalysed by UPP2, UPP1, CDAcytosol

• inosineReach from here →
  1. deoxyuridine:orthophosphate 2-deoxy-D-ribosyltransferase
  2. uridine:phosphate alpha-D-ribosyltransferase
  3. inosine + UMP = uridine + IMP

  Catalysed by UPP2, UPP1, NT5C2cytosolOne of 3 routes

• thymidineReach from here →
  1. ATP:deoxyuridine 5'-phosphotransferase
  2. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  3. thymidylate 5'-phosphohydrolase

  Catalysed by TK1, TYMS, ACP3, NT5E and 8 morecytosolOne of 4 routes

• CHEBI:17808Reach from here →
  1. deoxyuridine:orthophosphate 2-deoxy-D-ribosyltransferase
  2. uridine:phosphate alpha-D-ribosyltransferase
  3. uridine/cytidine kinase (ITP)

  Catalysed by UPP2, UPP1, UCK2, UCK1cytosol

• CHEBI:17895Reach from here →
  1. thymidine kinase (deoxyuridine)
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:18019Reach from here →
  1. thymidine kinase (deoxyuridine)
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• L-glutamineReach from here →
  1. thymidine kinase (deoxyuridine)
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• dTDPReach from here →
  1. ATP:deoxyuridine 5'-phosphotransferase
  2. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  3. DTDP Diphosphohydrolase

  Catalysed by TK1, TYMS, ENTPD3, ENTPD1 and 1 morecytosol, extracellular spaceOne of 9 routes

• dTTPReach from here →
  1. ATP:deoxyuridine 5'-phosphotransferase
  2. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  3. dTTP + H2O = dTMP + diphosphate + H(+)

  Catalysed by TK1, TYMS, ASMTLcytosolOne of 4 routes

• thioredoxin disulfideReach from here →
  1. thymidine kinase (deoxyuridine)
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. 2'-deoxyadenosine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 12 routes

• N-carbamoyl-beta-alanineReach from here →
  1. deoxyuridine:orthophosphate 2-deoxy-D-ribosyltransferase
  2. 5,6-dihydrouracil:NAD+ oxidoreductase
  3. 5,6-Dihydrouracil amidohydrolase

  Catalysed by UPP2, UPP1, DPYScytosol

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by PKM, PKLR, AGXT2cytosol

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by PKM, PKLR, AGXT2cytosol

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by PKM, PKLR, AGXT2cytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. ATP:deoxyuridine 5'-phosphotransferase
  2. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  3. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase

  Catalysed by TK1, TYMS, DHFR, DHFR2cytosolOne of 3 routes

• folic acidReach from here →
  1. ATP:deoxyuridine 5'-phosphotransferase
  2. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  3. dihydrofolate:NAD+ oxidoreductase

  Catalysed by TK1, TYMS, DHFR, DHFR2cytosolOne of 2 routes

• L-aspartateReach from here →
  1. thymidine kinase (deoxyuridine)
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• acetateReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 3 morecytosol, extracellular spaceOne of 2 routes

• formic acidReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 3 morecytosol, extracellular spaceOne of 2 routes

• propionic acidReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

• butyric acidReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. L-Serine:pyruvate aminotransferase

  Catalysed by PKM, PKLR, AGXTcytosolOne of 2 routes

• 3-oxopropanoateReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by PKM, PKLR, AGXT2cytosol

• D-serineReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. D-serine = pyruvate + NH4(+)

  Catalysed by PKM, PKLR, SRRcytosol

• D-ribose 1-phosphateReach from here →
  1. deoxyuridine:orthophosphate 2-deoxy-D-ribosyltransferase
  2. uridine:phosphate alpha-D-ribosyltransferase
  3. uridine:phosphate alpha-D-ribosyltransferase

  Catalysed by UPP2, UPP1cytosol

• D-glucopyranose 6-phosphateReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dADP to dATP conversion
  3. dATP:D-glucose 6-phosphotransferase

  Catalysed by HK1, HK2, HK3, HKDC1cytosol, mitochondrial matrix

• (R)-lactic acidReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by PKM, PKLR, LDHDcytosol

• (S)-lactic acidReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by PKM, PKLR, LDHB, LDHAL6Bcytosol, mitochondrial matrixOne of 5 routes

• 2-iminopropanoateReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by PKM, PKLR, RIDAcytosol

• phosphoenolpyruvic acidReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. pyruvate kinase (dTDP)

  Catalysed by PKM, PKLRcytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by PKM, PKLR, NPLcytosol

• a 3-acylpyruvateReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by PKM, PKLR, FAHD1cytosol

• glycineReach from here →
  1. thymidine kinase (deoxyuridine)
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. ATP:deoxyuridine 5'-phosphotransferase
  2. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  3. (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)

  Catalysed by TK1, TYMS, DHFR, DHFR2cytosol

• (2R)-3-phospho-glyceroyl phosphateReach from here →
  1. 2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil
  2. 2-deoxy-alpha-D-ribose 1-phosphate + (2R)-3-phospho-glyceroyl phosphate = 2-deoxy-alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
  3. ATP:3-phospho-D-glycerate 1-phosphotransferase

  Catalysed by UPP2, UPP1, PGM2L1, PGK1 and 2 morecytosolOne of 2 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by PKM, PKLR, MPSTcytosol

• 2-methyl-3-oxopropanoateReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by PKM, PKLR, AGXT2cytosol

• alpha-D-ribose 1-phosphateReach from here →
  1. deoxyuridine:orthophosphate 2-deoxy-D-ribosyltransferase
  2. uridine:phosphate alpha-D-ribosyltransferase
  3. uridine + phosphate = alpha-D-ribose 1-phosphate + uracil

  Catalysed by UPP2, UPP1cytosol

• L-methionineReach from here →
  1. thymidine kinase (deoxyuridine)
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 3 routes

• L-tryptophanReach from here →
  1. thymidine kinase (deoxyuridine)
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• L-alanineReach from here →
  1. thymidine kinase (deoxyuridine)
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 20 routes

• L-asparagineReach from here →
  1. thymidine kinase (deoxyuridine)
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• IMPReach from here →
  1. thymidine kinase (deoxyuridine)
  2. ATP:dGMP phosphotransferase
  3. dGMP + inosine = 2'-deoxyguanosine + IMP

  Catalysed by GUK1, NT5C2cytosol

• L-phenylalanineReach from here →
  1. thymidine kinase (deoxyuridine)
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• (2R)-2-phosphoglycerateReach from here →
  1. 2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil
  2. 2-deoxy-alpha-D-ribose 1-phosphate + (2R)-3-phospho-glyceroyl phosphate = 2-deoxy-alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
  3. D-phosphoglycerate 2,3-phosphomutase

  Catalysed by UPP2, UPP1, PGM2L1, BPGM and 3 morecytosolOne of 2 routes

• dCDPReach from here →
  1. thymidine kinase (deoxyuridine)
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. 2'-deoxycytidine diphosphate:oxidized-thioredoxin 2'-oxidoreductase

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 20 routes

• (3S)-citramalyl-CoAReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by PKM, PKLR, CLYBLcytosol

• 5-amino-2-oxopentanoateReach from here →
  1. thymidine kinase (deoxyuridine)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by PKM, PKLR, AGXT2cytosol