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Proteins/UNIPROT:Q16774
Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors. In addition to its physiological role, GUK1 is essential for converting prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine..
Function from UniProtKB (Q16774), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
464 statements
464 statements · 4 reference databases · Subject: GUK1 · Sources: Bgee, Hetionet, Human-GEM, Reactome · Rows fetched: 300
4 reactions
Catalysed by GUK1
Reaction pageReversibleBalancedEC 2.7.4.8cytosol
Human-GEM MAR04020CC BY 4.0Reference data
Catalysed by GUK1
Reaction pageReversibleBalancedEC 2.7.4.8mitochondrial matrix
Human-GEM MAR04135CC BY 4.0
4 names
Resolves to: GUK1
Catalysed by GUK1
Reaction pageReversibleBalancedEC 2.7.4.8cytosol
Human-GEM MAR05353CC BY 4.0Reference data
Catalysed by GUK1
Reaction pageDirection not assertedBalanced
Rhea RHEA:20780CC BY 4.0Reference data