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Proteins/UNIPROT:P00558
Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis. May play a role in sperm motility..
Function from UniProtKB (P00558), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
147 statements
147 statements · 7 reference databases · Subject: PGK1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
3 reactions
(2R)-3-phospho-glyceroyl phosphate+ADP(2R)-3-phosphoglycerate+ATP
Catalysed by CRISP3 or PGK1 or PGK2
Reaction pageReversibleBalancedEC 2.7.2.3cytosol
Human-GEM MAR04368CC BY 4.0Reference data
(2R)-3-phosphoglycerate+ATP(4-)(2R)-3-phospho-glyceroyl phosphate+ADP(3-)
Catalysed by PGK1 or
4 names
Resolves to: PGK1
Reaction pageReversibleBalanced
Rhea RHEA:14801CC BY 4.0Reference data