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alpha-D-ribose 1-phosphate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

27 compounds within 3 steps: 3 in 1, 7 in 2, 17 in 3

Does it reach a compound?

One step

(2R)-3-phosphoglycerateReach from here →
1. (2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
Catalysed by PGM2L1
alpha-D-ribose 1,5-bisphosphateReach from here →
1. (2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
Catalysed by PGM2L1
D-ribose 5-phosphateReach from here →
1. alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
Catalysed by PGM2

Two steps

CDP-D-riboseReach from here →
1. alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
2. D-ribose 5-phosphate + CTP + H(+) = CDP-D-ribose + diphosphate
Catalysed by PGM2, CRPPA
(R)-glycerateReach from here →
1. (2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
2. (R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+)
Catalysed by PGM2L1, GLYCTK
D-riboseReach from here →

Three steps

nicotinic acid D-ribonucleotideReach from here →
Catalysed by PGM2, PRPS2, PRPS1L1, PRPS1 and 1 morecytosolOne of 2 routes
CHEBI:15842Reach from here →

alpha-D-ribose 1-phosphate = D-ribose 5-phosphate

D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)

Catalysed by PGM2, RBKS

(2R)-3-phospho-glyceroyl phosphateReach from here →

(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
ATP:3-phospho-D-glycerate 1-phosphotransferase

Catalysed by PGM2L1, PGK1, PGK2, CRISP3cytosolOne of 2 routes

ADP-D-riboseReach from here →

alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
D-ribose 5-phosphate + ATP + H(+) = ADP-D-ribose + diphosphate

Catalysed by PGM2, NUDT5

5-phospho-alpha-D-ribose 1-diphosphateReach from here →

alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)

Catalysed by PGM2, PRPS2, PRPS1L1, PRPS1

(2R)-2-phosphoglycerateReach from here →

(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
D-phosphoglycerate 2,3-phosphomutase

Catalysed by PGM2L1, BPGM, PGAM2, PGAM1 and 1 morecytosolOne of 2 routes

Catalysed by PGM2, PRPS2, PRPS1L1, PRPS1 and 1 morecytosol

NMN zwitterionReach from here →

alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)
nicotinamide-D-ribonucleotide:diphosphate phospho-alpha-D-ribosyltransferase

Catalysed by PGM2, PRPS2, PRPS1L1, PRPS1 and 1 morecytosolOne of 2 routes

3-hydroxypyruvateReach from here →

(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+)
(R)-glycerate + NAD(+) = 3-hydroxypyruvate + NADH + H(+)

Catalysed by PGM2L1, GLYCTK, GRHPROne of 2 routes

CHEBI:17202Reach from here →

alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)
IMP:diphosphate phospho-D-ribosyltransferase

Catalysed by PGM2, PRPS2, PRPS1L1, PRPS1 and 1 morecytosol

CHEBI:17797Reach from here →

alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
D-ribose 5-phosphate + ATP + H(+) = ADP-D-ribose + diphosphate
ADPribose Diphosphatase, Mitochondrial

Catalysed by PGM2, NUDT5, NUDT9mitochondrial matrixOne of 2 routes

CHEBI:29052Reach from here →

(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
ATP:3-phospho-D-glycerate 1-phosphotransferase
D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)

Catalysed by PGM2L1, PGK1, PGK2, CRISP3 and 2 morecytosol

phosphoenolpyruvic acidReach from here →

(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
D-phosphoglycerate 2,3-phosphomutase
2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)

Catalysed by PGM2L1, BPGM, PGAM2, PGAM1 and 4 morecytosol

XMPReach from here →

alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)
XMP:pyrophosphate phosphoribosyltransferase

Catalysed by PGM2, PRPS2, PRPS1L1, PRPS1 and 1 morecytosol

nicotinate beta-D-ribonucleotideReach from here →

alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)
nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)

Catalysed by PGM2, PRPS2, PRPS1L1, PRPS1 and 1 moreOne of 2 routes

orotidine 5'-phosphateReach from here →

alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)
orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate

Catalysed by PGM2, PRPS2, PRPS1L1, PRPS1 and 1 more

IMPReach from here →

alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate

Catalysed by PGM2, PRPS2, PRPS1L1, PRPS1 and 1 more

alpha-D-glucose 1,6-bisphosphateReach from here →

(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
ATP:3-phospho-D-glycerate 1-phosphotransferase
3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase

Catalysed by PGM2L1, PGK1, PGK2, CRISP3cytosolOne of 3 routes

5-phospho-beta-D-ribosylamineReach from here →

alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)
phosphoribosyl pyrophosphate amidotransferase (glutamine)

Catalysed by PGM2, PRPS2, PRPS1L1, PRPS1 and 1 morecytosolOne of 2 routes

phosphoenolpyruvateReach from here →

(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
D-phosphoglycerate 2,3-phosphomutase
(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O

Catalysed by PGM2L1, BPGM, PGAM2, PGAM1 and 5 morecytosol

D-glyceraldehyde 3-phosphateReach from here →

(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
ATP:3-phospho-D-glycerate 1-phosphotransferase
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)

Catalysed by PGM2L1, PGK1, PGK2, CRISP3 and 2 morecytosol

alpha-NAD(+)Reach from here →

alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
D-ribose 5-phosphate + ATP + H(+) = ADP-D-ribose + diphosphate
alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)

Catalysed by PGM2, NUDT5, MACROD2, ADPRH and 3 more