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Proteins/UNIPROT:Q9BZX2
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine..
Function from UniProtKB (Q9BZX2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
88 statements
88 statements · 5 reference databases · Subject: UCK2 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
9 reactions
CHEBI:16039+uridineproton+CHEBI:17808+UMP
Reaction pageLeft to rightBalancedEC 2.7.1.48cytosol
Human-GEM MAR03969CC BY 4.0Reference data
ATP+cytidineADP+cytidine 5'-monophosphate+proton
Catalysed by UCK1
5 names
Resolves to: UCK2
Reaction pageLeft to rightBalancedEC 2.7.1.48cytosol
Human-GEM MAR04180CC BY 4.0Reference data
cytidine+dUTPcytidine 5'-monophosphate+MAM01754c+proton
Reaction pageLeft to rightBalancedEC 2.7.1.48cytosol
Human-GEM MAR04676CC BY 4.0Reference data
Catalysed by UCK1 or UCK2 or UCKL1
Reaction pageLeft to rightBalancedEC 2.7.1.48cytosol
Human-GEM MAR05299CC BY 4.0Reference data
Catalysed by UCK1 or UCK2 or UCKL1
Reaction pageLeft to rightBalancedEC 2.7.1.48cytosol
Human-GEM MAR05301CC BY 4.0Reference data
dUTP+uridineMAM01754c+proton+UMP
Catalysed by UCK1 or UCK2 or UCKL1
Reaction pageLeft to rightBalancedEC 2.7.1.48cytosol
Human-GEM MAR05352CC BY 4.0Reference data
ATP+cytidineADP+cytidine 5'-monophosphate+proton
Catalysed by UCK1 or UCK2 or UCKL1
Reaction pageLeft to rightBalancedEC 2.7.1.48mitochondrial matrix
Human-GEM MAR08445CC BY 4.0Reference data
uridine+ATP(4-)UMP+ADP(3-)+hydron
Catalysed by UCK2 or UCK1 or UCKL1
Reaction pageDirection not assertedBalanced
Rhea RHEA:16825CC BY 4.0Reference data
cytidine+ATP(4-)CMP+ADP(3-)+hydron
Catalysed by UCK2 or UCK1 or UCKL1
Reaction pageDirection not assertedBalanced
Rhea RHEA:24674CC BY 4.0Reference data