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Proteins/UNIPROT:P04183
Cell-cycle-regulated enzyme of importance in nucleotide metabolism. Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate. Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT)..
Function from UniProtKB (P04183), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
359 statements
359 statements · 5 reference databases · Subject: TK1 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
3 reactions
Catalysed by TK1
Reaction pageLeft to rightBalancedEC 2.7.1.21cytosol
Human-GEM MAR04054CC BY 4.0Reference data
ATP+2'-deoxyuridineADP+dUMP+proton
Catalysed by TK1
Reaction pageLeft to right
1 name
Resolves to: TK1
Human-GEM MAR04641CC BY 4.0Reference data
thymidine+ATP(4-)dTMP+ADP(3-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:19129CC BY 4.0Reference data