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Proteins/UNIPROT:Q7LG56

RRM2B

Protein·UNIPROT:Q7LG56

Open in the graph

Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage..

Function from UniProtKB (Q7LG56), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

6 rows

adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy has a germline basis in RRM2BDiseaseGenCC HGNC:17296|MONDO:0018002Inferred only
autosomal dominant progressive external ophthalmoplegia has a germline basis in RRM2BDiseaseGenCC HGNC:17296|MONDO:0008003Inferred only
Kearns-Sayre syndrome has a germline basis in RRM2BDiseaseGenCC HGNC:17296|MONDO:0010787Inferred only
mitochondrial DNA depletion syndrome 8a has a germline basis in RRM2BDiseaseGenCC HGNC:17296|MONDO:0012792Inferred only
mitochondrial neurogastrointestinal encephalomyopathy has a germline basis in RRM2BDiseaseGenCC HGNC:17296|MONDO:0017575Inferred only
progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 5 has a germline basis in RRM2BDiseaseGenCC HGNC:17296|MONDO:0013117Inferred only

Statements

47 statements

47 statements · 7 reference databases · Subject: RRM2B · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Search this listOrder

RRM2B covaries with GNRH2ProteinHetionet hetionet:covaries:2797-50484Inferred only
RRM2B covaries with GPC5ProteinHetionet hetionet:covaries:2262-50484Inferred only
RRM2B interacts with ATRIPProteinHetionet hetionet:interacts:50484-84126Inferred only
RRM1 interacts with RRM2BProteinHetionet hetionet:interacts:50484-6240Inferred only
RRM2 interacts with RRM2BProteinHetionet hetionet:interacts:50484-6241Inferred only
TP53 interacts with RRM2BProteinHetionet hetionet:interacts:50484-7157Inferred only
UBA52 interacts with RRM2BProteinHetionet hetionet:interacts:50484-7311Inferred only
RRM2B participates in Biomarkers for pyrimidine metabolism disordersPathwayWikiPathways WP4584Inferred only
RRM2B participates in DNA damage responsePathwayWikiPathways WP707Inferred only
RRM2B participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
RRM2B participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
RRM2B participates in Interconversion of nucleotide di- and triphosphatesPathwayReactome R-HSA-499943Inferred only

Show the remaining 35

RRM2B participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
RRM2B participates in Metabolism of nucleotidesPathwayReactome R-HSA-15869Inferred only
RRM2B participates in miRNA regulation of DNA damage responsePathwayWikiPathways WP1530Inferred only
RRM2B participates in Nucleotide metabolismPathwayWikiPathways WP404Inferred only
RRM2B participates in p53 transcriptional gene networkPathwayWikiPathways WP4963Inferred only
RRM2B participates in Purine metabolism and related disordersPathwayWikiPathways WP4224Inferred only
RRM2B participates in Pyrimidine metabolismPathwayWikiPathways WP4022Inferred only
RRM2B participates in Pyrimidine metabolism and related diseasesPathwayWikiPathways WP4225Inferred only
RRM2B participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
RRM2B participates in TP53 Regulates Metabolic GenesPathwayReactome R-HSA-5628897Inferred only
RRM2B participates in Transcriptional Regulation by TP53PathwayReactome R-HSA-3700989Inferred only
RRM2B regulates positive regulation of G0 to G1 transitionBiological processgene ontology Q7LG56|GO:0070318Inferred only
RRM2B regulates positive regulation of G2/M transition of mitotic cell cycleBiological processgene ontology Q7LG56|GO:0010971Inferred only
RRM2B requires the cofactor iron cationCompoundUniProt Q7LG56Inferred only
a ribonucleoside 5'-diphosphate is a substrate of RRM2BCompoundRhea RHEA:23252Inferred only
CHEBI:16174 is a substrate of RRM2BCompoundHuman-GEM MAR02352Inferred only
CHEBI:16174 is a substrate of RRM2BCompoundHuman-GEM MAR05415Inferred only
CHEBI:28862 is a substrate of RRM2BCompoundHuman-GEM MAR02357Inferred only
CHEBI:28862 is a substrate of RRM2BCompoundHuman-GEM MAR05416Inferred only
dUTP is a substrate of RRM2BCompoundHuman-GEM MAR06621Inferred only
thioredoxin disulfide is a substrate of RRM2BCompoundHuman-GEM MAR02352Inferred only
thioredoxin disulfide is a substrate of RRM2BCompoundHuman-GEM MAR06621Inferred only
thioredoxin disulfide is a substrate of RRM2BCompoundHuman-GEM MAR05416Inferred only
thioredoxin disulfide is a substrate of RRM2BCompoundHuman-GEM MAR05415Inferred only
thioredoxin disulfide is a substrate of RRM2BCompoundHuman-GEM MAR02357Inferred only
thioredoxin dithiol is a substrate of RRM2BCompoundHuman-GEM MAR04619Inferred only
thioredoxin dithiol is a substrate of RRM2BCompoundHuman-GEM MAR04618Inferred only
thioredoxin dithiol is a substrate of RRM2BCompoundHuman-GEM MAR04611Inferred only
thioredoxin dithiol is a substrate of RRM2BCompoundHuman-GEM MAR06622Inferred only
thioredoxin dithiol is a substrate of RRM2BCompoundHuman-GEM MAR04612Inferred only
thioredoxin dithiol is a substrate of RRM2BCompoundHuman-GEM MAR04614Inferred only
thioredoxin dithiol is a substrate of RRM2BCompoundHuman-GEM MAR04615Inferred only
thioredoxin dithiol is a substrate of RRM2BCompoundHuman-GEM MAR04617Inferred only
thioredoxin dithiol is a substrate of RRM2BCompoundHuman-GEM MAR06621Inferred only
thioredoxin dithiol is a substrate of RRM2BCompoundHuman-GEM MAR04621Inferred only

Reactions

15 reactions

CHEBI:16174+water+thioredoxin disulfideADP+thioredoxin dithiol
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1mitochondrial matrix
Human-GEM MAR02352CC BY 4.0Reference data
CHEBI:28862+

Other names

3 names

Resolves to: RRM2B

Also called: p53-inducible ribonucleotide reductase small subunit 2-like proteinP53R2TP53-inducible ribonucleotide reductase M2 B

← Every protein Find it in the graph →

+thioredoxin disulfide

→

+thioredoxin dithiol

Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B

Reaction pageLeft to rightBalancedEC 1.17.4.1mitochondrial matrix

Human-GEM MAR02357CC BY 4.0Reference data

ATP+thioredoxin dithiolCHEBI:16284+water+thioredoxin disulfide

Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B

Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol

Human-GEM MAR04611CC BY 4.0Reference data

ADP+thioredoxin dithiolCHEBI:16174+water+thioredoxin disulfide

Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B

Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol

Human-GEM MAR04612CC BY 4.0Reference data

GTP+thioredoxin dithiolCHEBI:16497+water+thioredoxin disulfide

Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B

Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol

Human-GEM MAR04614CC BY 4.0Reference data

GDP+thioredoxin dithiolCHEBI:28862+water+thioredoxin disulfide

Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B

Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol

Human-GEM MAR04615CC BY 4.0Reference data

CHEBI:17677+thioredoxin dithioldCTP+water+thioredoxin disulfide

Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B

Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol

Human-GEM MAR04617CC BY 4.0Reference data

thioredoxin dithiol+UTPdUTP+water+thioredoxin disulfide

Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B

Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol

Human-GEM MAR04618CC BY 4.0Reference data

CHEBI:17239+thioredoxin dithioldCDP+water+thioredoxin disulfide

Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B

Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol

Human-GEM MAR04619CC BY 4.0Reference data

thioredoxin dithiol+UDPMAM01754c+water+thioredoxin disulfide

Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B

Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol

Human-GEM MAR04621CC BY 4.0Reference data

CHEBI:16174+water+thioredoxin disulfideADP+thioredoxin dithiol

Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B

Reaction pageLeft to rightBalancedEC 1.17.4.1mitochondrial matrix

Human-GEM MAR05415CC BY 4.0Reference data

CHEBI:28862+water+thioredoxin disulfideGDP+thioredoxin dithiol

Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B

Reaction pageLeft to rightBalancedEC 1.17.4.1mitochondrial matrix

Human-GEM MAR05416CC BY 4.0Reference data

Show the remaining 3