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Proteins/UNIPROT:P52790
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate..
Function from UniProtKB (P52790), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
64 statements
64 statements · 7 reference databases · Subject: HK3 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
13 reactions
ATP+beta-D-fructoseADP+keto-D-fructose 6-phosphate+proton
Catalysed by HKDC1 or HK1 or HK2 or HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04319CC BY 4.0Reference data
3 names
Resolves to: HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1, 2.7.1.2, 2.7.1.147cytosol
Human-GEM MAR04394CC BY 4.0Reference data
D-glucose+CHEBI:16039D-glucopyranose 6-phosphate+proton+CHEBI:17808
Catalysed by HKDC1 or HK1 or HK2 or HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04486CC BY 4.0Reference data
CHEBI:16284+D-glucoseCHEBI:16174+D-glucopyranose 6-phosphate+proton
Catalysed by HKDC1 or HK1 or HK2 or HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04487CC BY 4.0Reference data
beta-D-fructose+CHEBI:16039keto-D-fructose 6-phosphate+proton+CHEBI:17808
Catalysed by HKDC1 or HK1 or HK2 or HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04488CC BY 4.0Reference data
CHEBI:16284+beta-D-fructoseCHEBI:16174+keto-D-fructose 6-phosphate+proton
Catalysed by HKDC1 or HK1 or HK2 or HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04489CC BY 4.0Reference data
ATP+D-mannoseADP+proton+MAM02455c
Catalysed by HKDC1 or HK1 or HK2 or HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04490CC BY 4.0Reference data
CHEBI:16039+D-mannoseproton+CHEBI:17808+MAM02455c
Catalysed by HKDC1 or HK1 or HK2 or HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04492CC BY 4.0Reference data
CHEBI:16284+D-mannoseCHEBI:16174+proton+MAM02455c
Catalysed by HKDC1 or HK1 or HK2 or HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04493CC BY 4.0Reference data
ATP+glucosamineADP+alpha-D-glucosamine 6-phosphate+proton
Catalysed by GCK or HKDC1 or HK1 or HK2 or HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04494CC BY 4.0Reference data
D-fructose+ATP(4-)D-fructose 6-phosphate+ADP(3-)+hydron
Catalysed by HK1 or GCK or HK2 or HK3
Reaction pageLeft to rightBalanced
Rhea RHEA:16125CC BY 4.0Reference data
D-glucose+ATP(4-)D-glucose 6-phosphate+ADP(3-)+hydron
Catalysed by HK1 or GCK or HK2 or HK3 or HKDC1
Reaction pageLeft to rightBalanced
Rhea RHEA:17825CC BY 4.0Reference data