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Proteins/UNIPROT:P00491
Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine..
Function from UniProtKB (P00491), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
1 row
620 statements
620 statements · 8 reference databases · Subject: PNP · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
12 reactions
inosine+phosphate(3-)hypoxanthine+D-ribose 1-phosphate
Catalysed by PNP
Reaction pageReversibleBalancedEC 2.4.2.1cytosol
Human-GEM MAR04574CC BY 4.0Reference data
MAM00639c+guanine2'-deoxyguanosine+phosphate(3-)
Catalysed by PNP
Reaction pageReversibleBalancedEC 2.4.2.1, 2.4.2.4cytosol
3 names
Resolves to: PNP
guanosine+phosphate(3-)guanine+D-ribose 1-phosphate
Catalysed by PNP
Reaction pageReversibleBalancedEC 2.4.2.15, 2.4.2.1cytosol
Human-GEM MAR04651CC BY 4.0Reference data
phosphate(3-)+xanthosineD-ribose 1-phosphate+xanthine
Catalysed by PNP
Reaction pageReversibleBalancedEC 2.4.2.1cytosol
Human-GEM MAR04663CC BY 4.0Reference data
MAM00639c+adenine2'-deoxyadenosine+phosphate(3-)
Catalysed by PNP
Reaction pageReversibleBalancedEC 2.4.2.1, 2.4.2.4cytosol
Human-GEM MAR04695CC BY 4.0Reference data
MAM00639c+hypoxanthine2'-deoxyinosine+phosphate(3-)
Catalysed by PNP
Reaction pageReversibleBalancedEC 2.4.2.1, 2.4.2.4cytosol
Human-GEM MAR04709CC BY 4.0Reference data
adenosine+phosphate(3-)adenine+D-ribose 1-phosphate
Catalysed by PNP
Reaction pageReversibleBalancedEC 2.4.2.1cytosol
Human-GEM MAR08486CC BY 4.0Reference data
proton+nicotinamide+D-ribose 1-phosphatebeta-nicotinamide D-riboside+phosphate(3-)
Catalysed by PNP
Reaction pageReversibleBalancedEC 2.4.2.1cytosol
Human-GEM MAR08791CC BY 4.0Reference data
guanosine+hydrogenphosphatealpha-D-ribose 1-phosphate+guanine
Reaction pageLeft to rightBalanced
Rhea RHEA:13233CC BY 4.0Reference data
inosine+hydrogenphosphatealpha-D-ribose 1-phosphate+hypoxanthine
Reaction pageLeft to rightBalanced
Rhea RHEA:27646CC BY 4.0Reference data
2'-deoxyguanosine+hydrogenphosphate2-deoxy-alpha-D-ribose 1-phosphate+guanine
Catalysed by PNP
Reaction pageDirection not assertedBalanced
Rhea RHEA:27738CC BY 4.0Reference data
2'-deoxyinosine+hydrogenphosphate2-deoxy-alpha-D-ribose 1-phosphate+hypoxanthine
Catalysed by PNP
Reaction pageDirection not assertedBalanced
Rhea RHEA:27750CC BY 4.0Reference data