pyruvate

1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

Catalysed by AGXT2, SLC7A10mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. CTP:N-acetylneuraminate cytidylyltransferase

Catalysed by NPL, CMAScytosol, nucleusOne of 2 routes

1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2. transport of alanine and tryptophan (cytosol to extracellular)

Catalysed by AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 8 routes

1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

Catalysed by AGXT2, SLC7A10mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 5 routes

1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

Catalysed by AGXT2, KYNUmitochondrial matrix

1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

Catalysed by AGXT2, SLC7A10mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

1. L-Serine:pyruvate aminotransferase
2. hydroxypyruvate aldose-ketose-isomerase

Catalysed by AGXT, HYIcytosolOne of 2 routes

1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2. transport of alanine and asparagine (cytosol to extracellular)

Catalysed by AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 9 routes

1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2. transport of alanine and phenylalanine (cytosol to extracellular)

Catalysed by AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 12 routes

1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

Catalysed by AGXT2, KYNUmitochondrial matrix

1. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
2. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

Catalysed by TYW1B, TYW1, BHMT2

1. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
2. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

Catalysed by TYW1B, TYW1, BHMT2

1. transport of acetate and pyruvate (cytosol to extracellular)
2. N-acetylputrescine + H2O = putrescine + acetate

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 2 moreextracellular space, cytosol

1. pyruvate kinase (dTDP)
2. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)

Catalysed by PKM, PKLR, ENO1, ENO2 and 1 morecytosol

1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

Catalysed by AGXT2mitochondrial matrixOne of 7 routes

1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

Catalysed by AGXT2, SLC1A4mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
2. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O

Catalysed by MPST, AADATOne of 2 routes

1. transport of acetate and pyruvate (cytosol to extracellular)
2. N(8)-acetylspermidine + H2O = spermidine + acetate

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 2 moreextracellular space, cytosol

1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2. L-3-amino-isobutanoate:2-oxoglutarate aminotransferase

Catalysed by AGXT2, ABATmitochondrial matrix

1. Pyruvate:carbon-dioxide ligase (ADP-forming)
2. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2

Catalysed by PC, PCK1, PCK2mitochondrial matrix

1. transport of acetate and pyruvate (cytosol to extracellular)
2. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 2 moreextracellular space, cytosol

1. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
2. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

Catalysed by TYW1B, TYW1, MSRA

1. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
2. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

Catalysed by TYW1B, TYW1, MSRB3, MSRB1 and 1 more

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 moreOne of 2 routes

1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

Catalysed by AGXT2, SLC1A4mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2. gamma-glutamyltransferase (alanine)

Catalysed by AGXT2, GGTLC3, GGT1, GGT5 and 3 moremitochondrial matrix, cytosolOne of 2 routes

1. pyruvate kinase (dTDP)
2. DTDP Diphosphohydrolase

Catalysed by PKM, PKLR, ENTPD3, ENTPD1 and 1 morecytosol, extracellular spaceOne of 5 routes

1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by AGXT2, MOCOSmitochondrial matrix

1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

Catalysed by AGXT2mitochondrial matrixOne of 6 routes

1. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
2. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)

Catalysed by AGXT2, RIDA

1. D-serine = pyruvate + NH4(+)
2. D-serine = 2-aminoprop-2-enoate + H2O

Catalysed by SRR

1. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
2. thromboxane B2(out) + 2 (S)-lactate(in) = thromboxane B2(in) + 2 (S)-lactate(out)

Catalysed by LDHA, LDHB, LDHC, LDHAL6A and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

1. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
2. 2-(alpha-hydroxyethyl)thiamine-diphosphate[m] + lipoamide[m] = S-acetyldihydrolipoamide[m] + thiamin-PP[m]

Catalysed by PDHA1, PDHB, PDHA2, DLATmitochondrial matrix

1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2. transport of alanine and tryptophan (cytosol to extracellular)
3. beta-carboline hydrolysis

Catalysed by AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosol

1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
2. 2-Methyl-3-oxopropanoate:NAD+ oxidoreductase (CoA-propanoylating)
3. Active Transport

Catalysed by AGXT2,